Name: Gö 6976
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₄H₁₈N₄O

CAS Number:

136194-77-9

分子量:

378.43

MDL编号:

MFCD00236434

UNSPSC代码:

12352200

PubChem化学物质编号:

329799832

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方案

≥98% (HPLC)

表单

powder

颜色

white

溶解性

DMSO: >5 mg/mL

储存温度

−20°C

SMILES字符串

Cn1c2ccccc2c3c4C(=O)NCc4c5c6ccccc6n(CCC#N)c5c13

InChI

1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)

InChI key

VWVYILCFSYNJHF-UHFFFAOYSA-N

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应用

Gö 6976 has been used:

as an inhibitor of protein kinase C (PKC) in mammalian cell lines
as a PKCμ inhibitor in oocytes
as a PKC-α to test its effect on phosphorylation of protein kinase-B (Akt) and extracellular-signal-regulated kinase (ERK) levels

生化/生理作用

Go¨6976 also acts as an effective inhibitor of protein kinase C isoform (PKCμ) and abolishes phorbol ester mediated potentiation in oocytes. It inhibits PKC α and β selectively. Go-6976 may also inhibit S6-kinase 1.

Gö 6976 is an inhibitor of protein kinase C (PKC) specific for α (IC₅₀=2.3 nM) and β1 (IC₅₀=6.2 nM) isozymes.