G1269
Gly-Arg-Gly-Asp-Ser-Pro-Lys
≥97% (HPLC)
别名:
GRGDSPK
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关于此项目
经验公式（希尔记法）:
C28H49N11O11
化学文摘社编号:
分子量:
715.76
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
human
biological source
human
Quality Level
assay
≥97% (HPLC)
form
powder
technique(s)
blocking: suitable, ligand binding assay: suitable
storage temp.
−20°C
SMILES string
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O
InChI
1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1
InChI key
ZRVZOBGMZWVJOS-VMXHOPILSA-N
Gene Information
human ... ITGA2B(3674), ITGAV(3685)
General description
Gly-Arg-Gly-Asp-Ser-Pro-Lys是一种RGD肽。作为胞外基质(ECM)蛋白中的天然RGD肽，参与促进整合素介导的细胞与基质蛋白的黏附。RGD肽在细胞黏附蛋白（如纤连蛋白和玻连蛋白）中以重复形式存在。这种三肽被细胞中特定的整合素（如β1、β3和β5亚基）识别，存在于细胞表面，通过粘着斑(FA)复合物与肌动蛋白丝关联。
Application
Gly-Arg-Gly-Asp-Ser-Pro-Lys（RGD肽）已用于
- 作为抑制肽抑制整合素和纤连蛋白的结合
- 通过猪滋养外胚层粘附实验研究TGFβ（转化生长因子）对细胞粘附的影响
- 培养MC3T3-E1成骨细胞，通过AFM（原子力显微镜）检测其对细胞粘附的影响作用
- 制备RGD.Flt23k.NR纳米颗粒
- 确定RGD-整合素连接在细胞粘附过程中的参与
Biochem/physiol Actions
结合整合素的纤连蛋白类似物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Pierre-Henri Puech et al.
Journal of cell science, 118(Pt 18), 4199-4206 (2005-09-13)
During vertebrate gastrulation, progenitor cells of different germ layers acquire specific adhesive properties that contribute to germ layer formation and separation. Wnt signals have been suggested to function in this process by modulating the different levels of adhesion between the
J Holland et al.
Biomaterials, 17(22), 2147-2156 (1996-11-01)
A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)
Christine Selhuber-Unkel et al.
Biophysical journal, 95(11), 5424-5431 (2008-08-12)
We have studied the initial phase of cell adhesion as a function of the lateral organization of individual integrin molecules with single-cell force microscopy. Nanostructures, consisting of hexagonally ordered gold dots, were prepared with diblock-copolymer micelle lithography and functionalized with
Yang Kyung Cho et al.
Investigative ophthalmology & visual science, 53(4), 2328-2336 (2012-03-20)
To determine if nanoparticles delivering plasmids expressing Flt23k (an anti-VEGF intraceptor) can enhance murine cornea transplant survival and whether their effect is synergistic with steroid therapy. Biodegradable PLGA Flt23k loaded or blank nanoparticles were prepared using the emulsion solvent evaporation
E J Filardo et al.
The Journal of cell biology, 130(2), 441-450 (1995-07-01)
The NPXY sequence is highly conserved among integrin beta subunit cytoplasmic tails, suggesting that it plays a fundamental role in regulating integrin-mediated function. Evidence is provided that the NPXY structural motif within the beta 3 subunit, comprising residues 744-747, is
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G1269-1MG | 04061826738627 |
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