G1274
HA-1004 hydrochloride
≥98% (HPLC), powder
别名:
N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C12H15N5O2S · HCl
化学文摘社编号:
分子量:
329.81
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C12H15N5O2S.ClH/c13-12(14)16-6-7-17-20(18,19)11-3-1-2-9-8-15-5-4-10(9)11;/h1-5,8,17H,6-7H2,(H4,13,14,16);1H
SMILES string
Cl.NC(=N)NCCNS(=O)(=O)c1cccc2cnccc12
InChI key
GUGJQAFPKZZOIV-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: 10 mM, ethanol: 10 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
Shown to be an intracellular calcium antagonist. Reported to induce neurite formation.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H Tsushima et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 8(12), 1317-1328 (1998-01-07)
Erythropoietin (Epo) is a cytokine known to stimulate proliferation and differentiation of erythroid cells. However, recent gene disruption experiments demonstrated that Epo receptor signaling is not an obligatory step in erythroid differentiation. Here, we describe the role of Epo in
J C Leahy et al.
Neuroscience, 44(2), 361-370 (1991-01-01)
The effects of the isoquinolinesulfonamide protein kinase inhibitors 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) and N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA1004) on CA1 responses in hippocampal slices of the rat were examined to clarify their mode of action, and also to further define the role of Ca(2+) -dependent
M R Crowley et al.
Journal of cardiovascular pharmacology, 23(5), 806-813 (1994-05-01)
HA1004, an isoquinolinesulfonamide and a cyclic nucleotide-dependent protein kinase inhibitor, is an intracellular calcium antagonist that produces vascular smooth muscle (VSM) relaxation in vitro. We studied the hemodynamic effects of intravenous (i.v.) infusions of HA1004 (0.1-2.0 mg/kg) in vivo in
A Fex Svenningsen et al.
Journal of neuroscience research, 52(5), 530-537 (1998-06-19)
Schwann cell proliferation was studied in cultured segments of the rat sciatic nerve by measurement of [3H] thymidine incorporation or through bromodeoxyuridine-(BrdU)-labelling and immunocytochemistry. The aim was to delineate mechanisms involved in the injury-induced proliferative response of Schwann cells. Removal
T Hiwasa et al.
Neuroscience letters, 238(3), 115-118 (1998-02-17)
The effects of various inhibitors on the glial cell line-derived neurotrophic factor (GDNF)-induced neurite formation in TGW human neuroblastoma cells were investigated. Treatment of cells with Ser/Thr protein kinase inhibitors such as staurosporine, H-7, H-8 and HA-1004, induced neurite formation
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