一般描述
Human gelsolin (also known as brevin) is an actin severing protein found in mammalian cells and blood plasma. Gelsolins consist of a 730 amino acid core structure which contains six repeated domains. These six domains make up three distinct actin binding sites. The plasma enzyme contains an N-terminal extension of 25 amino acids that raises its molecular weight from 90 kD to 93 kD.
应用
Plasma gelsolin levels may be used to identify patients at risk for increased morbidity.
生化/生理作用
Gelsolin is an actin-severing protein found in mammalian cells and blood plasma. Exhibits tumor suppressor activity in several cancer cell lines and in nude mice.
Gelsolin is an actin-binding protein that regulates the assembly and disassembly of actin filaments.
包装
Package size based on protein content
外形
Lyophilized powder containing Tris buffer salts, pH 7.6, NaCl, DTT, and EGTA
其他说明
One unit will reduce viscosity difference between actin solution and buffer by 50% in a 1 mL mixture containing 1-2 mg F-actin, 0.15 M KCl, 20 mM Tris, pH 7.6, 0.2 mM CaCl2, 0.2 mM ATP and 1 mM DTT at 28°C.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Po-Shun Lee et al.
Annals of surgery, 243(3), 399-403 (2006-02-24)
To examine the relationship between plasma gelsolin levels and mortality following surgery or trauma. Few simple predictive diagnostic tests are available to predict mortality following surgery or trauma. We hypothesize that plasma concentrations of gelsolin, a protein that responds to
Eun Young Park et al.
Bioscience reports, 32(4), 393-400 (2012-05-30)
The plasma level of LPA (lysophosphatidic acid) (200-600 nM) is well within the range that promotes proliferation and migration of vascular ECs (endothelial cells), yet vessels are quiescent and stable. In this report, we considered one explanation for this paradox:
Markus Ganter et al.
Molecular microbiology, 74(6), 1356-1367 (2009-08-18)
Summary Successful malaria transmission from the mosquito vector to the mammalian host depends crucially on active sporozoite motility. Sporozoite locomotion and host cell invasion are driven by the parasite's own actin/myosin motor. A unique feature of this motor machinery is
D Wen et al.
Biochemistry, 35(30), 9700-9709 (1996-07-30)
Gelsolin is a widely distributed actin binding protein that regulates actin filament length. It exists in both an intracellular and an extracellular form that is derived from a single gene by alternative splicing. Both forms contain the six homologous domains
R C Koya et al.
The Journal of biological chemistry, 275(20), 15343-15349 (2000-05-16)
Apoptotic cell death, characterized by chromatin condensation, nuclear fragmentation, cell membrane blebbing, and apoptotic body formation, is also accompanied by typical mitochondrial changes. The latter includes enhanced membrane permeability, fall in mitochondrial membrane potential (Deltapsi(m)) and release of cytochrome c
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