G3011
谷胱甘肽还原酶 来源于菠菜
Type VI, ammonium sulfate suspension, 100-200 units/mg protein
别名:
GR, NAD(P)H: oxidized-glutathione oxidoreductase
type
Type VI
form
ammonium sulfate suspension
specific activity
100-200 units/mg protein
mol wt
118 kDa
foreign activity
NADPH oxidase ≤0.01%
storage temp.
2-8°C
Biochem/physiol Actions
A crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the process is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. The enzyme uses FAD as a cofactor. GR and glutathione peroxidase may inhibit lipid peroxidation by functioning as antioxidant enzymes in sperm. Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and α/β hydrolases. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems.
Physical form
Suspension in 3.6 M (NH4)2SO4 mM, 10 mM potassium phosphate, pH 7.0
Other Notes
One unit will reduce 1.0 μmole of oxidized glutathione per min at pH 7.6 at 25°C. (Protein determined by biuret).
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
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