G3011
谷胱甘肽还原酶 来源于菠菜
Type VI, ammonium sulfate suspension, 100-200 units/mg protein
别名:
GR, NAD(P)H: oxidized-glutathione oxidoreductase
类型
Type VI
表单
ammonium sulfate suspension
比活
100-200 units/mg protein
分子量
118 kDa
异质活性
NADPH oxidase ≤0.01%
储存温度
2-8°C
生化/生理作用
A crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the process is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. The enzyme uses FAD as a cofactor. GR and glutathione peroxidase may inhibit lipid peroxidation by functioning as antioxidant enzymes in sperm. Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and α/β hydrolases. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems.
外形
Suspension in 3.6 M (NH4)2SO4 mM, 10 mM potassium phosphate, pH 7.0
其他说明
One unit will reduce 1.0 μmole of oxidized glutathione per min at pH 7.6 at 25°C. (Protein determined by biuret).
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Biomedicine. Asthmatics breathe easier when it's SNO-ing.
Craig Gerard
Science (New York, N.Y.), 308(5728), 1560-1561 (2005-06-11)
Vineet Bhandari et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(29), 11021-11026 (2006-07-13)
VEGF, nitric oxide (NO), inflammation, and vascular- and extravascular remodeling coexist in asthma and other disorders. In these responses, VEGF regulates angiogenesis. VEGF also induces inflammation and remodeling. The mechanisms of the latter responses have not been defined, however. We
Roberto M Saraiva et al.
Current opinion in cardiology, 21(3), 221-228 (2006-04-08)
The role played by nitric oxide (NO) in cardiovascular physiology remains highly controversial. Following the discovery that NO is the prototypic endothelium-derived relaxing factor, this signaling molecule was implicated as possessing many other biological actions within the cardiovascular system, including
Rupam Sahoo et al.
Free radical biology & medicine, 40(4), 625-631 (2006-02-07)
Oxidative stress has been shown to alter cellular redox status in various cell types. Changes in expressions of several antioxidative and antistress-responsive genes along with activation or inactivation of various proteins were also reported during oxidative insult as well as
Edward M Henderson et al.
Trends in molecular medicine, 11(11), 481-484 (2005-10-11)
Conventionally, asthma is defined as involving both airway inflammation and airway smooth muscle hyper-responsiveness. However, Que and coworkers have recently uncoupled these concepts, showing that mice lacking an S-nitrosothiol reductase have allergen-induced airway inflammation but do not have airway hyper-responsiveness.
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