G4795
Anti-GLUT10 (SLC2A10) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Glucose Transporter 10, Anti-Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 10
Quality Level
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~57 kDa by calculation
species reactivity
human
technique(s)
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... SLC2A10(81031)
Immunogen
peptide corresponding to the human GLUT10 protein (amino acids 367-385).
Biochem/physiol Actions
GLUT10 is a glucose transporter that is encoded by the gene SLC2A10, and is highly expressed in liver and pancreas. Polymorphisms in SLC2A10 may not influence the pathogenesis of type 2 diabetes but the expression of GLUT10 and the interaction with TGF-β signaling pathway has important role in the development of peripheral arterial disease in patients with type 2 diabetes. GLUT10 is also required for the development of cardiovascular system and the notochord in zebrafish embryos.
Physical form
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Gitte Andersen et al.
Diabetes, 52(9), 2445-2448 (2003-08-28)
The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. The gene is mapped to chromosome 20q12-q13.1, a region that has been shown to be linked to type 2 diabetes. The
Yi-Der Jiang et al.
BMC medical genetics, 11, 126-126 (2010-08-26)
Recent data indicate that loss-of-function mutation in the gene encoding the facilitative glucose transporter GLUT10 (SLC2A10) causes arterial tortuosity syndrome via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes in diabetes. We genotyped
Andy Willaert et al.
Human molecular genetics, 21(6), 1248-1259 (2011-11-26)
Growth factor signaling results in dramatic phenotypic changes in cells, which require commensurate alterations in cellular metabolism. Mutations in SLC2A10/GLUT10, a member of the facilitative glucose transporter family, are associated with altered transforming growth factor-β (TGFβ) signaling in patients with
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G4795-100UG | 04061835808038 |
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