G5168
（Z）-没药甾酮
≥89% (HPLC), bile acid receptor antagonist, powder
别名:
(17Z)-Pregna-4,17(20)-diene-3,16-dione, 4,17(20)-trans-Pregnadiene-3,16-dione
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关于此项目
经验公式（希尔记法）:
C21H28O2
化学文摘社编号:
分子量:
312.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
（Z）-没药甾酮, ≥89% (HPLC), powder
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)\C(=C\C)C(=O)C[C@@]24[H]
InChI key
WDXRGPWQVHZTQJ-OSJVMJFVSA-N
InChI
1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
assay
≥89% (HPLC)
form
powder
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
impurities
≤5.4% E-form
color
light yellow
solubility
DMSO: 5 mg/mL
application(s)
forensics and toxicology
veterinary
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.
(Z)-Guggulsterone is an antagonist ligand for bile acid receptor.
signalword
Warning
hcodes
Hazard Classifications
STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Inas Almazari et al.
Topics in current chemistry, 329, 35-60 (2012-08-02)
Guggulsterone (GS) is a phytosterol derived from the gum resin of guggul plants that have been used traditionally to treat various disorders such as burns, wounds, gastric ulcer, cough, gum diseases, urinary complaints, diarrhea, stomach cramps, fascioliasis, and intestinal worms.
Dongfang Yang et al.
Journal of lipid research, 53(3), 529-539 (2012-01-17)
Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is generally
Jeung-Hyun Koo et al.
International journal of molecular medicine, 30(4), 974-978 (2012-07-17)
In the present study, we investigated the effect of guggulsterone on melanogenesis in B16 melanoma cells and elucidated its possible mechanism of action. The effects of guggulsterone on melanogenesis were determined by assaying melanin synthesis and cellular tyrosinase activity in
R S Bhatta et al.
Biomedical chromatography : BMC, 25(9), 1054-1060 (2011-01-27)
A sensitive and selective liquid chromatography/tandem mass spectrometric method was developed for simultaneous determination of E- and Z-guggulsterone isomers (antihyperlipidemic drug) in rabbit plasma. Both the isomers were resolved on a Symmetry-Shield C(18) (5 µm, 4.6 × 150 mm) column, using gradient
Jae-Jun Song et al.
International journal of pediatric otorhinolaryngology, 74(12), 1384-1387 (2010-10-26)
Guggulsterone is a bioactive constituent of resinous sap originating from the guggul tree, Commiphora mukul, which has been used over several thousands of years to treat various diseases, including atherosclerosis, rheumatism, and obesity. However, the effect of guggulsterone inflammatory reactions
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