G5168
（Z）-没药甾酮
≥89% (HPLC), bile acid receptor antagonist, powder
别名:
(17Z)-Pregna-4,17(20)-diene-3,16-dione, 4,17(20)-trans-Pregnadiene-3,16-dione
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关于此项目
经验公式（希尔记法）:
C21H28O2
化学文摘社编号:
分子量:
312.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
（Z）-没药甾酮, ≥89% (HPLC), powder
Quality Level
assay
≥89% (HPLC)
form
powder
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤5.4% E-form
color
light yellow
solubility
DMSO: 5 mg/mL
application(s)
forensics and toxicology
veterinary
storage temp.
2-8°C
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)\C(=C\C)C(=O)C[C@@]24[H]
InChI
1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
InChI key
WDXRGPWQVHZTQJ-OSJVMJFVSA-N
Biochem/physiol Actions
(Z)-Guggulsterone is an antagonist ligand for bile acid receptor.
(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.
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signalword
Warning
hcodes
Hazard Classifications
STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Jeung-Hyun Koo et al.
International journal of molecular medicine, 30(4), 974-978 (2012-07-17)
In the present study, we investigated the effect of guggulsterone on melanogenesis in B16 melanoma cells and elucidated its possible mechanism of action. The effects of guggulsterone on melanogenesis were determined by assaying melanin synthesis and cellular tyrosinase activity in
Y T Kamal et al.
Biomedical chromatography : BMC, 26(10), 1183-1190 (2012-01-04)
An attempt has been made to develop and validate a simultaneous HPLC method for novel approach of drug release via oil-in-water (o/w) nanoemulsion formulation and Habb-e-Khardal Unani tablet containing piperine and guggul sterones E and Z as main ingredients. Nanoemulsion
Jae-Jun Song et al.
International journal of pediatric otorhinolaryngology, 74(12), 1384-1387 (2010-10-26)
Guggulsterone is a bioactive constituent of resinous sap originating from the guggul tree, Commiphora mukul, which has been used over several thousands of years to treat various diseases, including atherosclerosis, rheumatism, and obesity. However, the effect of guggulsterone inflammatory reactions
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G5168-25MG | 04061833261842 |
| G5168-5MG | 04061833633465 |