G5297
Glp-Asn-Pro-d-Tyr-d-Trp-NH2
≥98% (HPLC), solid
别名:
JAK4D
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关于此项目
经验公式（希尔记法）:
C34H40N8O8
化学文摘社编号:
分子量:
688.73
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C34H40N8O8/c35-28(44)16-26(41-31(47)23-11-12-29(45)38-23)34(50)42-13-3-6-27(42)33(49)40-25(14-18-7-9-20(43)10-8-18)32(48)39-24(30(36)46)15-19-17-37-22-5-2-1-4-21(19)22/h1-2,4-5,7-10,17,23-27,37,43H,3,6,11-16H2,(H2,35,44)(H2,36,46)(H,38,45)(H,39,48)(H,40,49)(H,41,47)/t23-,24+,25+,26-,27-/m0/s1
SMILES string
NC(=O)C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc3ccc(O)cc3)C(=O)N[C@H](Cc4c[nH]c5ccccc45)C(N)=O
InChI key
SZQSOKVXBMULDL-VQHLWIOESA-N
assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: >2 mg/mL
storage temp.
−20°C
Gene Information
rat ... TRH(7200), TRHDE(29953), TRHR(7201)
Biochem/physiol Actions
The synthetic peptide Glp-Asn-Pro-d-Tyr-d-Trp-NH2 mimics and amplifies central actions of TRH in rat without releasing TSH.
The synthetic peptide Glp-Asn-Pro-d-Tyr-d-Trp-NH2 mimics and amplifies central actions of TRH in rat without releasing TSH. Glp-Asn-Pro-d-Tyr-d-Trp-NH2 has dual pharmacological activities: it inhibits TRH-DE and binds to central TRH receptors with nM affinity in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRH receptor 1 (TRHR1) or TRH receptor 2 (TRHR2). The peptide can be a potent tool for probing the role of TRH actions in the CNS and a platform for development of novel TRH-based therapeutics for neuro diseases.
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
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