重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
lyophilized powder
组成
Protein, 3-5%
UniProt登记号
储存温度
−20°C
基因信息
human ... GRB2(2885)
生化/生理作用
A key protein in signal transduction, Grb2 transfers the signal from tyrosine kinases such as epidermal growth factor (EGF) receptor to the small G protein Ras. GRB2 contains an SH2 (Src homology 2) domain which enables binding to tyrosine-phosphorylated receptors. The fusion protein enables detection and purification of tyrosine-phosphorylated proteins (i.e., tyrosine-phosphorylated EGF receptor), utilizing the affinity of protein A for the Fc domain of IgG.
包装
Package size based on protein content
外形
Contains potassium phosphate and sodium chloride
其他说明
A 37 kDa fusion protein containing the SH2 domain of mouse Grb2 (amino acids 50-161) fused to protein A.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J P Olivier et al.
Cell, 73(1), 179-191 (1993-04-09)
A Drosophila gene (drk) encodes a widely expressed protein with a single SH2 domain and two flanking SH3 domains, which is homologous to the Sem-5 protein of C. elegans and mammalian GRB2. Genetic analysis suggests that drk function is essential
B Margolis
Progress in biophysics and molecular biology, 62(3), 223-244 (1994-01-01)
The cloning of SH2 domain proteins based on their binding to growth factor receptors is a powerful technique to elucidate new signaling pathways. In some cases the function of these proteins has been quickly ascertained while in others the answers
相关内容
Product Information Sheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持