G5794
GR 79236X
≥99% (HPLC), solid
别名:
N-[(1S, trans)-2-Hydroxycyclopentyl]adenosine
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关于此项目
经验公式（希尔记法）:
C15H21O5N5
化学文摘社编号:
分子量:
351.36
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C15H21N5O5/c21-4-9-11(23)12(24)15(25-9)20-6-18-10-13(16-5-17-14(10)20)19-7-2-1-3-8(7)22/h5-9,11-12,15,21-24H,1-4H2,(H,16,17,19)/t7-,8-,9+,11+,12+,15+/m0/s1
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N[C@H]4CCC[C@@H]4O)ncnc23
InChI key
GYWXTRVEUURNEW-TVDBPQCTSA-N
assay
≥99% (HPLC)
form
solid
color
white
solubility
H2O: 12 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
A1 adenosine receptor agonist
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
A D Kelion et al.
Heart (British Cardiac Society), 87(2), 115-120 (2002-01-18)
The "warm up" effect in angina may represent ischaemic preconditioning, which is mediated by adenosine A(1) receptors in most models. To investigate the effect of a selective A(1) agonist, GR79236 (GlaxoSmithKline), on exercise induced angina and ischaemic left ventricular dysfunction
J M Webster et al.
Biochimica et biophysica acta, 1316(2), 109-113 (1996-06-07)
The dose-response effects of a new adenosine agonist, GR79236, were examined in isolated rat soleus muscle strips and human rectus abdominus muscle strips. Effects on the insulin sensitivity of carbohydrate metabolism were examined, in particular upon insulin stimulated glycogen synthesis
J R Sneyd et al.
British journal of anaesthesia, 98(5), 672-676 (2007-04-10)
Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain. Seventy-nine patients with moderate pain after third molar extraction under general anaesthesia were randomized to
C J Gardner et al.
European journal of pharmacology, 257(1-2), 117-121 (1994-05-12)
GR79236 (N-[(1S,trans)-2-hydroxycyclopentyl]adenosine) is an orally active adenosine A1 receptor agonist, which decreases plasma non-esterified fatty acid levels in fasted rats. This study has quantified the effects of GR79236 on plasma non-esterified fatty acid levels, blood pressure and heart rate in
P J Goadsby et al.
Brain : a journal of neurology, 125(Pt 6), 1392-1401 (2002-05-23)
There is a considerable literature to suggest that adenosine A1 receptor agonists may have anti-nociceptive effects, and we sought to explore the role of adenosine A1 receptors in a model of trigeminovascular nociceptive transmission. Cats were anaesthetized (alpha-chloralose 60 mg/kg
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