Product Name
抗- 胶质纤维酸性蛋白抗体，小鼠单克隆, clone G-A-5, purified from hybridoma cell culture
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
G-A-5, monoclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
rat, human, pig
浓度
~1.0 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect immunofluorescence: 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum.
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GFAP(2670)
mouse ... Gfap(14580)
pig ... GFAP(396562)
rat ... Gfap(24387)
一般描述
神经胶质原纤维酸性蛋白（GFAP）是存在于星形胶质细胞中的中间丝，以10种不同的亚型进行表达。它由N端头部、中心杆和C端尾部结构域组成。GFAP位于人类染色体17q21.33。
免疫原
纯化的猪脊髓 GFAP。
应用
神经胶质纤维酸性蛋白单克隆抗体适用于蛋白印迹和间接免疫荧光（2.5-5 μg/mL，使用酒精固定的大鼠脑/小脑切片）。该抗体还可用于免疫印迹（约50 kDa）、免疫组化（多聚甲醛固定的兔脑冷冻切片）和免疫细胞化学。
神经胶质纤维酸性蛋白抗体（小鼠单克隆抗体）可用于免疫细胞化学和免疫荧光。
生化/生理作用
神经胶质纤维酸性蛋白或GFAP组装与神经胶质结构的有丝分裂重塑有关。GFAP基因突变与亚历山大病有关。
神经胶质纤维酸性蛋白（GFAP）基因位点的微缺失与儿童智力残疾和面部畸形有关。GFAP水平升高与急性脑出血有关。
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
M Inagaki et al.
Brain pathology (Zurich, Switzerland), 4(3), 239-243 (1994-07-01)
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein of astroglia, and belongs to the type III subclass of IF proteins. IF proteins are composed of an amino-terminal HEAD domain, a central ROD domain and a carboxyterminal TAIL
Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation
Ito K, et al.
Scientific Reports, 6, 23903-23903 (2016)
Plasma glial fibrillary acidic protein in the differential diagnosis of intracerebral hemorrhage
Katsanos AH, et al.
Stroke, 48(9), 2586 -22588 (2017)
Novel organotypic in vitro slice culture model for intraventricular hemorrhage of premature infants.
Govindaiah Vinukonda et al.
Journal of neuroscience research, 90(11), 2173-2182 (2012-07-19)
Mechanisms of brain injury in intraventricular hemorrhage (IVH) of premature infants are elusive, and no therapeutic strategy exists to prevent brain damage in these infants. Therefore, we developed an in vitro organotypic forebrain slice culture model to advance mechanistic studies
Seila Fernandez-Fernandez et al.
Redox biology, 19, 52-61 (2018-08-15)
Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not been unambiguously elucidated. Previous attempts to address this issue were approached
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持