Anti-GGH (167-180) antibody produced in rabbit

γ-Glutamyl hydrolase is a lysosomal and secreted glycoprotein that is abundantly expressed in liver and kidney. It may be used as a target for inhibition to enhance the therapeutic effect of antifolates and fluorouracil.

synthetic peptide corresponding to amino acids 167-180 of human GGH

Anti-GGH antibody produced in rabbit is suitable for western blot analysis at a working dilution of 1:500-1:2000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

GGH (γ-glutamyl hydrolase) encodes an enzyme that hydrolyzes the γ-glutamyl sidechains of antifolate and folate polyglutamates. Removal of γ-glutamyl residues from pteroylpoly-γ-glutamate yields pteroyl-α-glutamate (folic acid) and free glutamate.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

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