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Merck
CN

G7897

Sigma-Aldrich

Granuliberin R

≥97% (HPLC)

别名:

Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH2

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关于此项目

经验公式（希尔记法）:
C69H103N19O14
化学文摘社编号:
64704-41-2
分子量:
1422.68
MDL编号:
MFCD00080191
UNSPSC代码:
12352200
PubChem化学物质编号:
24895328

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方案

≥97% (HPLC)

储存温度

−20°C

SMILES字符串

CCC(C)C(NC(=O)C1CCCN1C(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)CNC(=O)C(N)Cc3ccccc3)C(=O)NC(Cc4ccc(O)cc4)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N5CCCC5C(=O)NC(C)C(=O)NC(CO)C(N)=O

InChI

1S/C69H103N19O14/c1-6-40(4)56(86-64(99)54-24-16-32-88(54)67(102)51(33-39(2)3)84-61(96)49(35-43-19-11-8-12-20-43)80-55(91)37-78-59(94)46(70)34-42-17-9-7-10-18-42)65(100)83-50(36-44-25-27-45(90)28-26-44)62(97)81-47(21-13-29-76-68(72)73)60(95)82-48(22-14-30-77-69(74)75)66(101)87-31-15-23-53(87)63(98)79-41(5)58(93)85-52(38-89)57(71)92/h7-12,17-20,25-28,39-41,46-54,56,89-90H,6,13-16,21-24,29-38,70H2,1-5H3,(H2,71,92)(H,78,94)(H,79,98)(H,80,91)(H,81,97)(H,82,95)(H,83,100)(H,84,96)(H,85,93)(H,86,99)(H4,72,73,76)(H4,74,75,77)

InChI key

IQNSWGKGZHMSIZ-UHFFFAOYSA-N

生化/生理作用

Mast cell degranulating peptide found in the skin of the frog, Rana rugosa.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
088H0031
018H0813
079F06652

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A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin.
T Nakajima et al.
Chemical & pharmaceutical bulletin, 25(9), 2464-2465 (1977-09-01)
J Lechago et al.
Neuroscience, 12(1), 329-337 (1984-05-01)
The histamine-releasing peptide "granuliberin", originally isolated from the skin of Rana rugosa, was localized by immunofluorescence within nerve cell bodies and fibers in the brain of Rana pipiens. The granuliberin-positive neurons were characterized ultrastructurally by electron microscopic observation of ultrathin
Marcin Kozakiewicz et al.
Cellular & molecular biology letters, 8(3), 727-734 (2003-09-02)
To assess the effect of substances inducing mast cell degranulation (substance P and granuliberin R) on the mitotic indices of the gingiva stratified epithelium, basal cells from rats were studied in vivo. Seventy Lewis male rats were used in the
Synthesis of granuliberin-R and various fragment peptides and their histamine-releasing activities.
C Kitada et al.
Chemical & pharmaceutical bulletin, 28(3), 887-892 (1980-03-01)

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