Anti-phospho-Growth Associated Protein-43 (pSer⁴¹) antibody produced in rabbit

synthetic phosphopeptide derived from the region of rat GAP-43 phosphorylated on serine 41.

Anti-phospho-Growth Associated Protein-43 (pSer41) antibody produced in rabbit is suitable for immunoblotting at a working dilution of 1:1000.

GAP-43 is an intracellular phosphoprotein that is present exclusively in the peripheral and central nervous systems. Protein kinase C (PKC) phosphorylates GAP-43 on a single site, serine 41. This phosphorylated protein is found in the areas where growth cones make productive and stable contacts with other cells. It facilitates stabilization of long actin filaments. Phosphorylation by PKC at serine 41 is related to nerve-terminal sprouting and long-term potentiation as high levels of GAP-43 are present in neocortical areas and in the limbic system. It is crucial in mediating experience dependent plasticity.

Solution in 10 mM HEPES, pH 7.5, containing 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

An additional band at 150-160 kDa may be detected and reflects the oligomeric nature of GAP-43.

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