G9423
GYPGQV trifluoroacetate salt
≥98% (HPLC), powder
别名:
Gly-Tyr-Pro-Gly-Gln-Val trifluoroacetate salt, Glycyl-L-tyrosyl-L-prolyl-glycyl-L-glutaminyl-L-valine trifluoroacetate salt, PAR 4 (1-6)
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关于此项目
经验公式（希尔记法）:
C28H41N7O9
分子量:
619.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
H2O: >2 mg/mL
storage temp.
−20°C
SMILES string
OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CN)C(O)=O
InChI
1S/C28H41N7O9.C2HF3O2/c1-15(2)24(28(43)44)34-25(40)18(9-10-21(30)37)32-23(39)14-31-26(41)20-4-3-11-35(20)27(42)19(33-22(38)13-29)12-16-5-7-17(36)8-6-16;3-2(4,5)1(6)7/h5-8,15,18-20,24,36H,3-4,9-14,29H2,1-2H3,(H2,30,37)(H,31,41)(H,32,39)(H,33,38)(H,34,40)(H,43,44);(H,6,7)/t18-,19-,20-,24-;/m0./s1
InChI key
QKXFYYGUAIKLHO-XESNDDQGSA-N
Application
GYPGQV trifluoroacetate salt has been used as a protease-activated receptor 4 (PAR4) peptide agonist to test its effect on guinea-pig lower esophageal sphincter.
Biochem/physiol Actions
GYPGQV peptide displays comparatively lower binding towards annexin than SFLLRN. It induces human platelet aggregation but not to the extent of GYPGKF peptide. GYPGQV is a weaker agonist of protease-activated receptor 4 (PAR4) signaling compared to AYPGKF.
Protease-activated receptor-4 (PAR4) agonist
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Soochong Kim et al.
Blood, 99(10), 3629-3636 (2002-05-03)
Thrombin is an important agonist for platelet activation and plays a major role in hemostasis and thrombosis. Thrombin activates platelets mainly through protease-activated receptor 1 (PAR1), PAR4, and glycoprotein Ib. Because adenosine diphosphate and thromboxane A(2) have been shown to
R T Dorsam et al.
Journal of thrombosis and haemostasis : JTH, 2(5), 804-812 (2004-04-22)
The activated platelet surface serves as an integral part of the prothrombinase complex upon activation by potent platelet agonists such as thrombin and collagen. We determined the receptor specificity through which thrombin was enhancing collagen-induced thrombin generation. Whereas SFLLRN or
Shih-Che Huang
Regulatory peptides, 142(1-2), 37-43 (2007-03-06)
Protease-activated receptor-1 (PAR1), PAR2 and PAR4 activation can alter the gastrointestinal motility. To investigate effects mediated by PARs in the lower esophageal sphincter, we measured contraction or relaxation of transverse strips from the guinea-pig lower esophageal sphincter caused by PAR1