Anti-GABA_A Receptor (β3 subunit), Cytosolic Loop antibody produced in rabbit

GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes. GABAA receptor is a ligand-gated chloride channel that is a multimeric subunit complex. So far, around 16 subunits have been identified. This gene encodes the β 3 subunit, which maps to human chromosome 15q11-13. Three human GABAA receptor subunit genes, GABRB3, GABRA5, and GABRG3, are expressed exclusively from the paternal allele.

fusion protein with the amino acid sequence representing the cytosolic loop of the rat GABA_A receptor (β3 subunit).

Anti-GABA_A Receptor (β 3 subunit), Cytosolic Loop antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat brain membrane fractions.

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. 155CA-2, a marker of GABRB3 has been associated with autistic disorder. Mutations in the β-3 subunit gene has also been linked to insomnia. The function of GABA receptor is inhibited by zinc ions based on the receptor subunit composition. The sites that mediate zinc inhibition are β-3 His267 and Glu270 located within the ion channel, and two more on the external N-terminal face of the receptor.

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.

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