生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, feline, mouse
技术
immunohistochemistry (frozen sections): 1:500
immunoprecipitation (IP): 1:100
indirect immunofluorescence: 1:500
western blot: 1:1,000
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
mouse ... Grm2(108068)
rat ... Grm2(24415)
一般描述
The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.
免疫原
synthetic peptide corresponding to the C-terminal region (13 amino acids) of mGluR2/3.
应用
Anti-Glutamate Receptor 2/3, Metabotropic (mGluR2/3) antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence at a working dilution of 1:500. It is suitable for immunoprecipitation at 1:100 and for immunoblotting at 1:1000 working dilution.
生化/生理作用
GRM2 and GRM3 belong to group II receptors and are involved in the inhibition of the cyclic AMP cascade. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are key regulators of excitatory amino acid neurotransmission in the striatum.
This antibody recognizes the C-terminal sequence shared by metabotropic glutamate receptors 2 and 3.
外形
Solution in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100μg/mL BSA, and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
法规信息
新产品
此项目有
A Makoff et al.
Brain research. Molecular brain research, 40(1), 55-63 (1996-08-01)
A human brain cDNA library was screened using amplified human metabotropic glutamate receptor (mGluR) cDNA sequences as probes. The resulting clones included one containing the complete coding sequence of mGluR3. This sequence has 90% DNA sequence identity with rat mGluR3
Carla Letizia Busceti et al.
eNeuro, 11(8) (2024-07-06)
Cognitive dysfunction is associated with methamphetamine use disorder (MUD). Here, we used genetic and pharmacological approaches to examine the involvement of either Group 2 metabotropic glutamate (mGlu2) or mGlu3 receptors in memory deficit induced by methamphetamine in mice. Methamphetamine treatment
P J Flor et al.
The European journal of neuroscience, 7(4), 622-629 (1995-04-01)
A cDNA encoding the human metabotropic glutamate receptor type 2 (hmGluR2) was isolated from human brain cDNA libraries by cross-hybridization with rat mGluR2 probes. The deduced amino acid sequence of the human mGluR2 receptor consists of 872 residues and shows
W Spooren et al.
Behavioural pharmacology, 14(4), 257-277 (2003-07-03)
Following the molecular cloning in the early 1990s of the metabotropic glutamate receptors (mGlu1-8), research that focused on the physiology, pharmacology and function of these receptors revealed their potential role in CNS disorders. Numerous psychiatric and neurological dis-orders are indeed
J P Pin et al.
Neuropharmacology, 34(1), 1-26 (1995-01-01)
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to
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