抗谷氨酸受体2/3，代谢型 (mGluR2/3) 兔抗

The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.

synthetic peptide corresponding to the C-terminal region (13 amino acids) of mGluR2/3.

Anti-Glutamate Receptor 2/3, Metabotropic (mGluR2/3) antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence at a working dilution of 1:500. It is suitable for immunoprecipitation at 1:100 and for immunoblotting at 1:1000 working dilution.

GRM2 and GRM3 belong to group II receptors and are involved in the inhibition of the cyclic AMP cascade. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are key regulators of excitatory amino acid neurotransmission in the striatum.

This antibody recognizes the C-terminal sequence shared by metabotropic glutamate receptors 2 and 3.

Solution in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100μg/mL BSA, and 50% glycerol.

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