运输
dry ice
储存温度
−20°C
应用
本品结合了与 FLAG 标签序列缀合的反应性膦，能与代谢纳入的叠氮糖相互作用。它允许通过一系列与得自 Sigma-Aldrich 的染料分子或固相载体相结合的 FLAG 试剂进行检测和/或富集。FLAG 系统可实现高特异性的相互作用，避免脱靶检测和不想要的污染。该系统还可避免不良毒性效应，这些毒性效应可能导致糖蛋白质组的表征不准确。
法律信息
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
GlycoProfile is a trademark of Sigma-Aldrich Co. LLC
法规信息
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Jennifer A Prescher et al.
Nature, 430(7002), 873-877 (2004-08-20)
Cell surfaces are endowed with biological functionality designed to mediate extracellular communication. The cell-surface repertoire can be expanded to include abiotic functionality through the biosynthetic introduction of unnatural sugars into cellular glycans, a process termed metabolic oligosaccharide engineering. This technique
C R Bertozzi et al.
Science (New York, N.Y.), 291(5512), 2357-2364 (2001-03-28)
Chemical tools have proven indispensable for studies in glycobiology. Synthetic oligosaccharides and glycoconjugates provide materials for correlating structure with function. Synthetic mimics of the complex assemblies found on cell surfaces can modulate cellular interactions and are under development as therapeutic
E Saxon et al.
Science (New York, N.Y.), 287(5460), 2007-2010 (2000-03-17)
Selective chemical reactions enacted within a cellular environment can be powerful tools for elucidating biological processes or engineering novel interactions. A chemical transformation that permits the selective formation of covalent adducts among richly functionalized biopolymers within a cellular context is
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