Anti-GM-CSF antibody produced in chicken

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as CSF-2, is encoded by the gene mapped to human chromosome 5q31-33. The encoded protein is expressed in a wide variety of immune cell types, including macrophages, mast cells and T cells, mainly in response to immune activation and inflammatory cytokines. In addition, it is also secreted in various non-immune cell types, such as endothelial cells, keratinocytes and fibroblasts, following the appropriate stimuli.

Immunogen Sequence: GI # 27437030, sequence 1-144

Recombinant colony stimulating factor 2

Anti-GM-CSF antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for indirect ELISA.

GM-CSF (Granulocyte-macrophage colony-stimulating factor) is a pleiotropic cytokine that regulates the growth and differentiation of granulocytes, macrophages, eosinophils and erythrocytes. The gene is present in a cluster along with interleukin-3 (IL-3), IL-4 and IL-5 on chromosome 5.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates binding of eosinophils to vascular cell adhesion molecule-1 and eosinophil migration into tissues. In addition, it is also implicated in maturation of antigen presenting cells. GM-CSF plays an essential role in modulation of surfactant homeostasis and alveolar macrophage innate immune responses in the lung. It also plays a vital role immune-independent tumor progression. Mutation in the gene is associated with the development of atopic asthma.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used in the treatment of neutropenia and leukemia in combination with chemotherapies. It plays a major role in proliferation and differentiation of granulocytes and macrophages from bone marrow progenitor cells. GM-CSF also play a vital role in immune regulation and hematopoiesis.

Solution in phosphate buffered saline containing 0.02% sodium azide.

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