GW21015
Anti-HRAS antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Anti-GTPase HRas, Anti-K-ras, Anti-N-ras, Anti-Transforming protein p21, Anti-V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1, Anti-c-H-ras, Anti-p21ras
生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, rat
制造商/商品名称
Genway 15-288-21015
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HRAS(3265)
免疫原
Immunogen Sequence: GI # 4885425, sequence 116-189
Recombinant V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1
应用
Anti-HRAS antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
GTPase HRas is an enzyme encoded by the HRAS gene in humans. It is located on the short (p) arm of chromosome 11 at position 15.5. Somatic mutation of this gene is restricted to a specific proportion of sporadic pheochromocytoma (PCC). It is strictly monomeric at comparable densities in solution and dimerization is a general property of native H-Ras on membrane surfaces. Missense mutation in the HRAS gene causes an autosomal-dominant syndrome, Costello syndrome.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Wan-Chen Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(8), 2996-3001 (2014-02-12)
The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A number of observations suggest that Ras is laterally organized within the cell membrane, and this may play a regulatory role in its activation. Lipid anchors composed
K Nicole Weaver et al.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 17(6), 421-430 (2014-08-19)
Costello syndrome is a rare, autosomal-dominant syndrome caused by activating missense mutations in the Harvey rat sarcoma viral oncogene homolog (HRAS), most often p.G12S. Several rare mutations have consistently been associated with a more severe phenotype that is often lethal
Lindsey Oudijk et al.
The Journal of clinical endocrinology and metabolism, 99(7), E1376-E1380 (2014-04-02)
Somatic or germline mutations in up to 15 disease-causative genes are detectable in up to 50% of patients with pheochromocytoma (PCC) and paraganglioma (PGL). Very recently, somatic H-RAS mutations were identified by exome sequencing in approximately 7% in sporadic PCCs
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