GW21015
Anti-HRAS antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Anti-GTPase HRas, Anti-K-ras, Anti-N-ras, Anti-Transforming protein p21, Anti-V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1, Anti-c-H-ras, Anti-p21ras
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, rat
manufacturer/tradename
Genway 15-288-21015
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HRAS(3265)
Immunogen
Immunogen Sequence: GI # 4885425, sequence 116-189
Recombinant V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1
Application
Anti-HRAS antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
GTPase HRas is an enzyme encoded by the HRAS gene in humans. It is located on the short (p) arm of chromosome 11 at position 15.5. Somatic mutation of this gene is restricted to a specific proportion of sporadic pheochromocytoma (PCC). It is strictly monomeric at comparable densities in solution and dimerization is a general property of native H-Ras on membrane surfaces. Missense mutation in the HRAS gene causes an autosomal-dominant syndrome, Costello syndrome.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Lindsey Oudijk et al.
The Journal of clinical endocrinology and metabolism, 99(7), E1376-E1380 (2014-04-02)
Somatic or germline mutations in up to 15 disease-causative genes are detectable in up to 50% of patients with pheochromocytoma (PCC) and paraganglioma (PGL). Very recently, somatic H-RAS mutations were identified by exome sequencing in approximately 7% in sporadic PCCs
Wan-Chen Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(8), 2996-3001 (2014-02-12)
The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A number of observations suggest that Ras is laterally organized within the cell membrane, and this may play a regulatory role in its activation. Lipid anchors composed
K Nicole Weaver et al.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 17(6), 421-430 (2014-08-19)
Costello syndrome is a rare, autosomal-dominant syndrome caused by activating missense mutations in the Harvey rat sarcoma viral oncogene homolog (HRAS), most often p.G12S. Several rare mutations have consistently been associated with a more severe phenotype that is often lethal
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