生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
制造商/商品名称
Genway 15-288-21029
技术
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... IL1B(3553)
一般描述
IL1B (interleukin-1β) is a major proinflammatory cytokine, which is secreted by macrophages and monocytes. It is secreted as an inactive enzyme called pro-IL-1β, which is then cleaved by IL-1β converting enzyme or caspase-1, to produce IL-1β. This gene is localized to human chromosome 2q13-21, and is composed of seven exons and six introns. It is a member of the IL-1 family, which also includes IL-1α and IL-1RN.
应用
Anti-Interleukin-1β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Interleukin-1 β (IL-1β), also known as catabolin, is a proinflammatory cytokine found to be involved in development of insulin resistance. It mediates the effect of macrophages on insulin signaling and proinflammatory response in human adipocytes. IL-1β blockage may be beneficial for preventing obesity-associated insulin resistance and inflammation in human adipose tissue. Its variants are implicated in the development of diabetic nephropathy (DN).
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Xuefeng Wang et al.
PloS one, 9(9), e106919-e106919 (2014-09-16)
The purpose of our study is to investigate the relationship between IL-1β -31C/T (rs1143627) and -511T/C (rs16944) polymorphisms and the preeclampsia (PE), and analyze the Linkage disequilibrium (LD) and haplotype frequency of the two polymorphism loci. Polymorphisms at -31C/T and
Ioannis Stefanidis et al.
DNA and cell biology, 33(7), 463-468 (2014-05-21)
Variants of the interleukin-1β gene (IL1B) are implicated in the development of diabetic nephropathy (DN). The present candidate-gene association study was conducted to investigate the association between the IL1B C-511T variant and the risk of DN in a Caucasian population.
Dan Gao et al.
American journal of physiology. Endocrinology and metabolism, 307(3), E289-E304 (2014-06-12)
Adipose tissue expansion during obesity is associated with increased macrophage infiltration. Macrophage-derived factors significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. Identification of the major factors that mediate detrimental effects of macrophages on adipocytes may offer potential
Yu He et al.
International orthopaedics, 38(8), 1671-1676 (2014-06-01)
Osteosarcoma is the most common childhood bone cancer. Interleukin-1 beta (IL-1B) is crucially involved in osteosarcoma carcinogenesis. Whether genetic polymorphisms of IL-1B also influence osteosarcoma risk is unknown. The aim of this study was to investigate the association between IL-1B
P E Auron et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(24), 7907-7911 (1984-12-01)
Interleukin 1 (IL-1) is a protein with several biological activities regulating host defense and immune responses. We report here the isolation of human IL-1 cDNA. It encodes a precursor polypeptide of 269 amino acids (30,747 Mr). mRNA isolated by hybridization
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