Anti-MIP-1β antibody produced in chicken

MIP-1β (macrophage inflammatory protein 1β) is a member of the CC chemokine (cysteine-cysteine) family, and is produced by monocytes and macrophages. This protein exists as a homodimer. It acts as a ligand to the GPCR (G-protein coupled receptor) called CCR5 (CC chemokine receptor 5).

Immunogen Sequence: GI # 4506845, sequence 27-92

Recombinant chemokine C-C motif ligand 4 isoform 1

Anti-MIP-1β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Chemokine (C-C motif) ligand 4 (CCL4) is a principal regulator of macrophage migration and signals through CCR5. CCR5 is linked to several protein kinases including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2 and members of the MAPK family that help in regulating macrophage chemotaxis. CCL4 is released at the site of inflammation in sarcoidosis.

Solution in phosphate buffered saline containing 0.02% sodium azide.

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