Anti-CCR2 antibody produced in chicken

CCR2 (chemokine (C-C motif) receptor 2) belongs to the chemokine receptor family, which are small (8-10kDa) G-protein coupled receptors (GPCR). This family is subdivided into four families called CC, CXC, CX3C and XC. CCR2 belongs to the CC family, and has its ligand-binding domain in its exoplasmic N-terminal. Its C-terminal is involved in intracellular signaling. It is constitutively expressed by monocytes, and is found on T-cells, naïve B-cells, NK (natural killer) cells, dendritic cells and basophils.

Immunogen Sequence: GI # 4502633, sequence 1-45

Recombinant chemokine (C-C motif) receptor 2 isoform A

Anti-CCR2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
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C-C chemokine receptor type 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration. CCR2 plays an important role in extravasation and transmigration of monocytes under inflammatory conditions. It is involved in the growth and invasion of prostate cancer (PCa). CCR2 expression is very important for CCL2-induced proliferation and invasion of PC-3M cells. CCR2 can also act as a promising molecular target for prevention of PCa growth and metastasis.

Solution in phosphate buffered saline containing 0.02% sodium azide.

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