生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
制造商/商品名称
Genway 15-288-21052
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... CKLF(51192)
应用
Anti-CKLF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Chemokine-like factor is a protein encoded by the CKLF gene in humans. It is the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family and its expression is differentially regulated in myoblasts and myotubes. CKLF has a major role in the recruitment and activation of leucocytes that plays an important role in the pathogenesis of allergic diseases. It can induce proliferation and inhibit apoptosis of human vascular smooth muscle cell by down-regulating Bax and Caspase-3 and by the up-regulation of Bcl-2 expression. CKLF1 may play an important role in inflammation and regeneration of skeletal muscle. It may also play an important role in the development of atopic dermatitis, in the process of immune and inflammatory responses of atherogenesis. CKLF1 is a useful marker for regenerating muscle fibers in inflammatory myopathies.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Gao-Yun Yang et al.
International journal of biological sciences, 9(8), 759-765 (2013-08-29)
Human chemokine-like factor 1 (CKLF1), a recently discovered chemokine, has a broad spectrum of biological functions in immune-mediated diseases. It is highly expressed on Th2 lymphocytes and is a functional ligand for human CCR4. CKLF1 has a major role in
Tao Zhang et al.
Zhonghua yi xue za zhi, 92(29), 2069-2074 (2012-12-21)
To explore the effects of chemokine-like factor 1 (CKLF1) on the growth and apoptosis of human vascular smooth muscle cell and understand its mechanism for the induction of cell apoptosis. After the transfection of human vascular smooth muscle cell with
W Han et al.
The Biochemical journal, 357(Pt 1), 127-135 (2001-06-21)
Cytokines are small proteins that have an essential role in the immune and inflammatory responses. The repertoire of cytokines is becoming diverse and expanding. Here we report the identification and characterization of a novel cytokine designated as chemokine-like factor 1
M H Chowdhury et al.
Acta neurologica Scandinavica, 118(2), 106-114 (2008-02-26)
We evaluated the expression of chemokine-like factor (CKLF) in biopsied muscle fibers in inflammatory myopathies, non-inflammatory myopathies and neurologically diseased controls. We studied the expression of CKLF in 15 polymyositis (PM), five dermatomyositis (DM), 15 non-inflammatory myopathies and nine neurologically
Luning Shao et al.
Cellular immunology, 263(2), 188-195 (2010-04-16)
Chemokine-like factor 1 (CKLF1) was the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family to be discovered. Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the
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