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Merck
CN

GW21074

Anti-Platelet Basic Protein antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

别名:

Anti-CXCL7, Anti-SCYB7, Anti-Small inducible cytokine B7

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21074

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PPBP(5473)

General description

PPBP (pro-platelet basic protein), also called CXCL7 (chemokine (C-X-C motif) ligand 7), is synthesized as a pro-peptide, which has a molecular weight of 14kDa. It undergoes proteolytic cleavage to produce multiple forms with different biological activities. The longest form produced post cleavage is called PPBP or LDGF (leukocyte-derived growth factor), and is a mitogen for fibroblast cells.

Immunogen

Immunogen Sequence: GI # 4505981, sequence 50-96
Recombinant pro-platelet basic protein

Application

Anti-Platelet Basic Protein antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

PPBP (pro-platelet basic protein), also called chemokine (C-X-C motif) ligand 7 (CXCL7), plays a role in immune response of human phagocytes against the intracellular bacteria. It is found at a significantly higher level in patients with rheumatoid arthritis, which is a chronic inflammatory disease. CXCL7 may act as a helper marker in the follow-up and treatment of developing cardiovascular risk.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.


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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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相关内容


Cumali Karatoprak et al.
Rheumatology international, 33(5), 1229-1232 (2012-10-12)
The activation of the platelets plays a key role in the formation of thrombosis. The variables such as mean platelet volume, platelet factor 4 and β-thromboglobulin have been used in the demonstration of the platelet activation. However, when the literature
Manoj M Pillai et al.
Blood, 107(9), 3520-3526 (2006-01-05)
The marrow microenvironment consists of several different interacting cell types, including hematopoietic-derived monocyte/macrophages and nonhematopoietic-derived stromal cells. Gene-expression profiles of stromal cells and monocytes cultured together differ from those of each population alone. Here, we report that CXCL7 gene expression
Carolina González-Cortés et al.
Immunobiology, 217(4), 394-401 (2011-11-22)
We have investigated the role of CXCL7 in the immune response of human phagocytes against the intracellular bacteria Mycobacterium tuberculosis and Legionella pneumophila. We have observed that polymorphonuclear neutrophil (PMN) chemotaxis induced by the supernatants of infected monocyte derived macrophages



全球贸易项目编号

货号GTIN
GW21074-50UG04061835783663