GW21358
Anti-ITGB4 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Anti-CD104, Anti-Integrin β-4
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21358
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ITGB4(3691)
Application
Anti-ITGB4 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Integrin, β 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a gene in humans. The downregulation of ITGB4 expression in airway epithelial cells could impair the antigen presentation ability of epithelial cells. It may help in regulating airway inflammation reaction in allergic asthma. ITGB4 expressions are positively correlated in gastric cancer cell lines and tissues and is associated with poor outcomes in gastric cancer patients. It may serve as a therapeutic target in the treatment of gastric cancer. Mutations in ITGB4 cause an autosomal recessive disorder, genodermatosisepidermolysis bullosa with pyloric atresia (EB-PA).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Zhong-Yin Yang et al.
Carcinogenesis, 34(12), 2851-2860 (2013-06-28)
MPS-1 (metallopanstimulin-1), also known as ribosomal protein S27, was overexpressed in gastric cancer cells. However, how MPS-1 contributes to gastric carcinogenesis has not been well characterized. Here, we show that high expression of MPS-1 was observed in gastric cancer tissues
L Pulkkinen et al.
American journal of human genetics, 63(5), 1376-1387 (1998-10-30)
Epidermolysis bullosa with pyloric atresia (EB-PA), an autosomal recessive genodermatosis, manifests with neonatal cutaneous blistering associated with congenital pyloric atresia. The disease is frequently lethal, but nonlethal cases have also been reported. Expression of the alpha6 beta4 integrin is altered
Chi Liu et al.
PloS one, 7(4), e32060-e32060 (2012-05-01)
Airway epithelial cells have been demonstrated to be accessory antigen presentation cells (APC) capable of activating T cells and may play an important role in the development of allergic airway inflammation of asthma. In asthmatic airways, loss of expression of
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