GW21358
Anti-ITGB4 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Anti-CD104, Anti-Integrin β-4
生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
制造商/商品名称
Genway 15-288-21358
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ITGB4(3691)
应用
Anti-ITGB4 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Integrin, β 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a gene in humans. The downregulation of ITGB4 expression in airway epithelial cells could impair the antigen presentation ability of epithelial cells. It may help in regulating airway inflammation reaction in allergic asthma. ITGB4 expressions are positively correlated in gastric cancer cell lines and tissues and is associated with poor outcomes in gastric cancer patients. It may serve as a therapeutic target in the treatment of gastric cancer. Mutations in ITGB4 cause an autosomal recessive disorder, genodermatosisepidermolysis bullosa with pyloric atresia (EB-PA).
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Zhong-Yin Yang et al.
Carcinogenesis, 34(12), 2851-2860 (2013-06-28)
MPS-1 (metallopanstimulin-1), also known as ribosomal protein S27, was overexpressed in gastric cancer cells. However, how MPS-1 contributes to gastric carcinogenesis has not been well characterized. Here, we show that high expression of MPS-1 was observed in gastric cancer tissues
L Pulkkinen et al.
American journal of human genetics, 63(5), 1376-1387 (1998-10-30)
Epidermolysis bullosa with pyloric atresia (EB-PA), an autosomal recessive genodermatosis, manifests with neonatal cutaneous blistering associated with congenital pyloric atresia. The disease is frequently lethal, but nonlethal cases have also been reported. Expression of the alpha6 beta4 integrin is altered
Chi Liu et al.
PloS one, 7(4), e32060-e32060 (2012-05-01)
Airway epithelial cells have been demonstrated to be accessory antigen presentation cells (APC) capable of activating T cells and may play an important role in the development of allergic airway inflammation of asthma. In asthmatic airways, loss of expression of
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