GW21429
Anti-ADAM23 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Anti-A disintegrin and metalloproteinase domain 23
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21429
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADAM23(8745)
Immunogen
Immunogen Sequence: GI # 4501913, sequence 72-144
Recombinant ADAM metallopeptidase domain 23 preproprotein
Application
Anti-ADAM23 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Disintegrin and metalloproteinase domain-containing protein 23 is an enzyme encoded by the ADAM23 gene in humans and is a member of a disintegrin and metalloprotease (ADAM) family. It is higly expressed in the brain and may function as integrin ligands in the brain along with other proteins. ADAM23 is associated with the progression of non-small-cell lung carcinoma (NSCLC) and its downregulation may be correlated with promoter methylation. It may be down-regulated by aberrant promoter hypermethylation during the progression of colorectal cancer. ADAM23 is down-regulated by methylation in brain tumors, which is a rare event.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
K Sagane et al.
The Biochemical journal, 334 ( Pt 1), 93-98 (1998-08-07)
Cellular disintegrins are a family of membrane-anchored proteins structurally related to snake venom disintegrins, and are potential regulators of cell-cell and cell-matrix interactions. The members of this protein family are also called ADAMs (a disintegrin and metalloproteinase) or MDC proteins
Fabrício F Costa et al.
Neuroscience letters, 380(3), 260-264 (2005-05-03)
The ADAMs comprises a family of cell surface proteins with putative roles in cell-cell and/or cell-matrix interactions and in protease activities. In this work, we have examined the expression level and the methylation status of the 5' upstream region of
Jin-Sung Choi et al.
International journal of cancer, 124(6), 1258-1262 (2008-12-18)
Promoter hypermethylation of the ADAM23 gene, which is normally involved in cell-to-cell and cell-to matrix adhesion, has been reported in pancreatic, breast and brain cancer, and recently the role of this gene was examined in gastric cancer. In this study
Chunyan Hu et al.
International journal of experimental pathology, 92(5), 333-339 (2011-03-25)
ADAM23, a member of a disintegrin and metalloprotease (ADAM) family, has been reported to be expressed in several types of tumours. The exact role of ADAM23 and the possible mechanisms in which it is involved in non-small-cell lung carcinoma (NSCLC)
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