GW21451
Anti-VAMP2 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Vesicle-associated membrane protein 2
生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human, rat, mouse
技术
immunocytochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... VAMP2(6844)
免疫原
Immunogen Sequence: GI # 7657675, sequence 43-93
Recombinant vesicle-associated membrane protein 2 (synaptobrevin 2)
应用
Anti-VAMP2 antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Vesicle-associated membrane protein 2 is a small integral membrane protein encoded by the VAMP2 gene in humans and is mapped on chromosome 17. It is a key component of the synaptic vesicle docking/fusion machinery and its mRNA. VAMP2 may be involved in the mechanism of action of antidepressants and may alter their efficacy. It is unlikely to play a major role in the efficacy of fluvoxamine. VAMP2 is recognized and cleaved by BoNT/B (Botulinum neurotoxin) and TeNT (tetanus neurotoxin) that possess similar organization.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Eva Lasič et al.
Biochimica et biophysica acta, 1861(9), 2293-2303 (2017-07-04)
Dynamin is a multidomain GTPase exhibiting mechanochemical and catalytic properties involved in vesicle scission from the plasmalemma during endocytosis. New evidence indicates that dynamin is also involved in exocytotic release of catecholamines, suggesting the existence of a dynamin-regulated structure that
Sicai Zhang et al.
Nature communications, 8(1), 1637-1637 (2017-11-22)
Botulinum neurotoxins (BoNTs), the most potent toxins known, are potential bioterrorism agents. It is well established that all seven serotypes of BoNTs (BoNT/A-G) require complex gangliosides as co-receptors. Here, we report that BoNT/DC, a presumed mosaic toxin between BoNT/D and
Wankun L Li et al.
eLife, 7 (2018-03-14)
The rodent olfactory bulb incorporates thousands of newly generated inhibitory neurons daily throughout adulthood, but the role of adult neurogenesis in olfactory processing is not fully understood. Here we adopted a genetic method to inducibly suppress adult neurogenesis and investigated
Gavin Hackett et al.
Toxins, 10(5) (2018-05-13)
We have purified and characterized recombinant botulinum neurotoxin serotype FA (BoNT/FA). This protein has also been named as a new serotype (serotype H), but the classification has been controversial. A lack of well-characterized, highly pure material has been a roadblock
Shinichi Saito et al.
Neuropsychobiology, 54(4), 226-230 (2007-03-16)
Vesicle-associated membrane protein 2 (VAMP2) is a key component of the synaptic vesicle docking/fusion machinery and its mRNA reportedly increases in the frontal cortex of rats following chronic antidepressant and electroconvulsive treatment. VAMP2 is therefore thought to be involved in
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