Anti-GADD45G antibody produced in chicken

The gene is mapped to human chromosome 9q22.1-q22.2 and contains a 477-bp open reading frame that encodes a protein of 159 amino acid residues. It is found to be expressed in heart, placenta, liver, skeletal muscle, prostate, testis, and ovary..[1] The active form of GADD45G (growth arrest and DNA-damage-inducible, γ) is a homodimer and its dimerization is essential for apoptosis and growth inhibition.[2]

Immunogen Sequence: GI # 5729836, sequence 1-159

Recombinant growth arrest and DNA-damage-inducible, gamma

GADD45G (growth arrest and DNA-damage-inducible, γ) gene encodes a protein that is expressed in increased levels under stress, growth arrest conditions and treatment with DNA-damaging agents such as UV (ultraviolet) and γ-irradiation. It mediates activation of MTK1/MEKK4 kinase (mitogen-activated protein kinase kinase kinase 4) upon environmental stress, which in turn activates p38 and JNK MAPK (c-Jun N-terminal kinase/ mitogen-activated protein kinase) pathways that regulate cell cycle and apoptosis. [1]The encoded protein functions in DNA repair, negative growth control, genomic stability, cell cycle checkpoints and apoptosis. [2]

Solution in phosphate buffered saline containing 0.02% sodium azide.

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