生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human, mouse, rat
制造商/商品名称
Genway 15-288-22307A
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... ADFP(123)
免疫原
Immunogen Sequence: GI # 34577059, sequence 71-240
Recombinant adipose differentiation-related protein
应用
Anti-ADFP (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Adipose differentiation-related protein is a protein encoded by the ADFP gene in humans. It plays a novel role in the regulation of macrophage autophagy during lipopolysaccharide (LPS) stimulation. ADFP is the most abundant lipid droplet (LD)-associated protein found in non-adipose tissue and its expression correlates with intracellular lipid accumulation. Its polymorphism may affect its function and influence the development of metabolic and cardiovascular diseases. It has been observed that prolonged endurance-type exercise training increases the expression of ADFP leading to increases in intramuscular triglyceride (IMTG) content in a type I muscle fiber-type specific manner in type 2 diabetes patients.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Rita Rinnankoski-Tuikka et al.
Metabolism: clinical and experimental, 63(8), 1031-1040 (2014-06-29)
The relation between lipid accumulation and influence of exercise on insulin sensitivity is not straightforward. A proper balance between lipid droplet synthesis, lipolysis, and oxidative metabolism would ensure low local intramyocellular fatty acid levels, thereby possibly protecting against lipotoxicity-associated insulin
Joëlle Magné et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(8), 3090-3099 (2013-04-23)
Perilipin 2 (PLIN2) is the most abundant lipid droplet (LD)-associated protein in nonadipose tissue, and its expression correlates with intracellular lipid accumulation. Here we identified a missense polymorphism, Ser251Pro, that has major effect on protein structure and function, along with
Xuyang Feng et al.
Lipids in health and disease, 13, 10-10 (2014-01-11)
Autophagy is an essential process for breaking down macromolecules and aged/damaged cellular organelles to maintain cellular energy balance and cellular nutritional status. The idea that autophagy regulates lipid metabolism is an emerging concept with important implications for atherosclerosis. However, the
C S Shaw et al.
American journal of physiology. Endocrinology and metabolism, 303(9), E1158-E1165 (2012-09-06)
The aim of the present study was to investigate changes in intramuscular triglyceride (IMTG) content and perilipin 2 expression in skeletal muscle tissue following 6 mo of endurance-type exercise training in type 2 diabetes patients. Ten obese male type 2
Laura Sanchez-Lazo et al.
Molecular endocrinology (Baltimore, Md.), 28(9), 1502-1521 (2014-07-25)
Oocyte meiotic maturation requires energy from various substrates including glucose, amino acids, and lipids. Mitochondrial fatty acid (FA) β-oxidation (FAO) in the oocyte is required for meiotic maturation, which is accompanied by differential expression of numerous genes involved in FAs
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