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Merck
CN

GW22390A

Anti-MAT2A antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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NACRES:
NA.41
UNSPSC Code:
12352203
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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

manufacturer/tradename

Genway 15-288-22390A

technique(s)

indirect ELISA: suitable, western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MAT2A(4144)

Immunogen

Immunogen Sequence: GI # 5174529, sequence 1-192
Recombinant methionine adenosyltransferase II, α

Application

Anti-MAT2A antibody produced in chicken is suitbale for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Methionine adenosyltransferase (MAT) is an enzyme responsible for S-adenosylmethionine (AdoMet) synthesis and is encoded by two genes, MAT1A and MAT2A. MAT1A and MAT2A encode for liver-specific and non-liver-specific MAT respectively. MAT2A expression is associated with lower AdoMet levels and a dedifferentiated phenotype. The gene expression is modulated as an adaptive response of the cell to l-methionine availability through its conversion to AdoMet. MAT2A is involved in the transmethylation pathway in the metabolic response to hyperoxia in lung epithelium.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Maria L Martínez-Chantar et al.
The Journal of biological chemistry, 278(22), 19885-19890 (2003-03-28)
In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. In liver, MAT1A expression is associated with high AdoMet levels and a differentiated phenotype, whereas MAT2A expression is associated with
Z Mao et al.
Biochemical and biophysical research communications, 248(3), 479-484 (1998-08-15)
Methionine adenosyltransferase (MAT) is a critical cellular enzyme which catalyzes the formation of S-adenosylmethionine, the principal methyl donor. In mammals, two different genes, MAT1A and MAT2A, encode for liver-specific and non-liver-specific MAT, respectively. We have cloned and characterized a 1.4-kb
Mihalis I Panayiotidis et al.
Free radical biology & medicine, 40(2), 348-358 (2006-01-18)
S-Adenosylmethionine (SAM, AdoMet) is the most important methyl donor used for synthesis of nucleic acids, phospholipids, creatine, and polyamines and for methylation of many bioactive molecules. The metabolic response of the lung to oxidative stress of hyperoxia requires increased RNA

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