生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, human, rat
制造商/商品名称
Genway 15-288-22423F
技术
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... PAFAH1B2(5049)
一般描述
PAFAH1B2 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 2) forms a component of platelet activating factor acetylhydrolase (paf-ah), which is composed of a regulatory subunit called Pafah1b1. The other two subunits are catalytic and non-identical and are called Pafah1b2 and Pafah1b3. This protein has a molecular weight of 30kDa. It is alternatively transcribed into two isoforms, which differ at their C-termini. One isoforms is specific to testis.
免疫原
Immunogen Sequence: GI # 4505585, sequence 1-229
Recombinant platelet-activating factor acetylhydrolase, isoform Ib, β subunit 30kDa
应用
Anti-PAFAH1B2 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Platelet-activating factor acetylhydrolase IB subunit β (PAFAH1B2) is a component of plasma PAF-AH, which can hydrolyze oxidized phospholipids and may attenuate the spreading of lipid peroxidation. It plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis. It forms a heterodimer with PAFAH1b3, in erythrocytes, and is responsible for rapid hydrolysis of aspirin.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Gang Zhou et al.
The Journal of biological chemistry, 288(17), 11940-11948 (2013-03-20)
Aspirin is rapidly hydrolyzed within erythrocytes by a heterodimer of PAFAH1b2/PAFAH1b3 but also in plasma by an unidentified activity. Hydrolysis in both compartments was variable, with a 12-fold variation in plasma among 2226 Cleveland Clinic GeneBank patients. Platelet inhibition by
Bruce T Scott et al.
Prostaglandins & other lipid mediators, 85(3-4), 69-80 (2007-12-25)
Platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis. Intracellular paf-ah (paf-ah-Ib) is composed of a regulatory subunit, Pafah1b1
Yutaka Hirashima et al.
Neurosurgery, 70(3), 602-609 (2011-08-26)
Free radicals and lipid peroxidation are thought to be related to the vasospasm generation after subarachnoid hemorrhage (SAH). Plasma platelet-activating factor-acetyl hydrolase (PAF-AH) degrades phospholipids with an oxidatively modified fatty acyl chain. To compare plasma PAF-AH activity and free forms
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