生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human, mouse
制造商/商品名称
Genway 15-288-22527F
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CAPG(822)
一般描述
CAPG (capping protein, gelsolin-like) is an actin-binding protein, which is expressed ubiquitously. It belongs to the Ca2+- and polyphosphoinositide-regulated villin/gelsolin superfamily, and caps the barbed end of the growing actin microfilament.
免疫原
Immunogen Sequence: GI # 4502561, sequence 1-348
Recombinant capping protein (actin filament), gelsolin-like
应用
Anti-CAPG antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Macrophage-capping protein (CAPG) plays a critical role in regulating the migration ability of cells. It is a Ca2+-sensitive protein, which reversibly blocks the barbed ends of actin filaments, but does not sever preformed actin filaments. CAPG helps in promoting tumor cell invasion, but not cell proliferation. It is involved in the process of metastasis by promoting the invasiveness of tumor cells. It can act as a biomarker in risk-stratification therapy for gastric cancer and as a therapeutic target in Hepatocellular carcinoma (HCC). CAPG is also identified as a novel candidate biomarker to predict response to gemcitabine treatment and survival in cholangiocarcinoma as well as lung adenocarcinoma.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
G A Dabiri et al.
The Journal of biological chemistry, 267(23), 16545-16552 (1992-08-15)
Macrophage capping protein (MCP) is a Ca(2+)-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. The human cDNA for MCP has been cloned and sequenced. The derived amino acid sequence predicts
Kazuya Kimura et al.
Journal of proteomics, 78, 362-373 (2012-10-23)
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide. We performed a proteomic study to understand the molecular mechanisms underlying metastasis in HCC. Among the 3491 protein spots observed by two-dimensional difference gel electrophoresis (2D-DIGE), we found that
Fangchun Shao et al.
The Tohoku journal of experimental medicine, 225(2), 95-101 (2011-09-13)
Gelsolin-like actin-capping protein (CapG), a ubiquitous actin-binding protein, has been shown to play a critical role in regulating the migration ability of cells. In this study, we investigated CapG expression in lung cancer cell lines under hypoxia and evaluated the
Hiroshi Ichikawa et al.
Journal of proteome research, 12(8), 3780-3791 (2013-06-21)
To reveal the proteomic background of lymph node metastasis (LNM) in gastric cancer, we performed a proteomic study of tumor and matched nontumor tissues obtained from surgically resected specimens of 22 patients with or without LNM. Using laser microdissection, we
Noriaki Morofuji et al.
Journal of proteomics, 75(5), 1577-1589 (2011-12-14)
Cholangiocarcinoma is one of the deadliest malignancies worldwide. Recent studies reported that treatment with gemcitabine was effective in prolonging survival. However, as the treatment only benefited a limited subset of patients, selection of patients before treatment is required. To discover
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