生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, human, rat
制造商/商品名称
Genway 15-288-22538F
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GRB2(2885)
一般描述
GRB2 (growth factor receptor-bound protein 2) is an adaptor protein, which is expressed ubiquitously. It is composed of two SH3 domains and one SH2 domain. The SH3 domains are present at the N- and C-termini, and are intervened by SH2 domain. It exists as a heterodimeric protein.
免疫原
Immunogen Sequence: GI # 4504111, sequence 1-217
Recombinant growth factor receptor-bound protein 2 isoform 1
应用
Anti-GRB2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Growth factor receptor-bound protein 2 (GRB2) is involved in signal transduction/cell communication. GRB2 controls fibroblast growth factor receptor 2 (FGFR2) signaling by regulating receptor kinase and SH2 domain-containing protein tyrosine phosphatase 2 (Shp2) phosphatase activities in the absence of extracellular stimulation. The protein is involved in the activation of the Ras signaling pathway. It helps in the regulation of Receptor tyrosine kinases (RTKs) signaling. GRB2 is associated with tyrosine-phosphorylated epidermal growth factor receptors (EGFRs) and platelet-derived growth factor receptors (PDGFRs) through its SH2 domain. It plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Li-Yan Li et al.
International journal of clinical and experimental pathology, 7(6), 3132-3140 (2014-07-18)
The adapter protein growth factor receptor-bound 2 (GRB2) is essential for various basic cellular functions by mediating the regulation of receptor tyrosine kinase (RTK) signaling, however, little is known about GRB2 expression in esophageal squamous cell carcinoma (ESCC). We sought
Zamal Ahmed et al.
The Journal of cell biology, 200(4), 493-504 (2013-02-20)
Constitutive receptor tyrosine kinase phosphorylation requires regulation of kinase and phosphatase activity to prevent aberrant signal transduction. A dynamic mechanism is described here in which the adaptor protein, growth factor receptor-bound protein 2 (Grb2), controls fibroblast growth factor receptor 2
Artur A Belov et al.
Science signaling, 5(249), pe49-pe49 (2012-11-08)
Receptor tyrosine kinases (RTKs) exhibit basal tyrosine phosphorylation and activity in the absence of ligand stimulation, which has been attributed to the "leaky" nature of tyrosine kinase autoinhibition and stochastic collisions of receptors in the membrane bilayer. This basal phosphorylation
E J Lowenstein et al.
Cell, 70(3), 431-442 (1992-08-07)
A cDNA clone encoding a novel, widely expressed protein (called growth factor receptor-bound protein 2 or GRB2) containing one src homology 2 (SH2) domain and two SH3 domains was isolated. Immunoblotting experiments indicate that GRB2 associates with tyrosine-phosphorylated epidermal growth
Nico J de Mol et al.
Biochimica et biophysica acta, 1834(2), 524-535 (2012-11-20)
The Grb2 adapter protein is involved in the activation of the Ras signaling pathway. It recruits the Sos protein by binding of its two SH3 domains to Sos polyproline sequences. We observed that the binding of Grb2 to a bivalent
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