Anti-PPP1CC antibody produced in chicken

Immunogen Sequence: GI # 4506007, sequence 1-323

Recombinant protein phosphatase 1, catalytic subunit, gamma isoform

Anti-PPP1CC antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Serine/threonine-protein phosphatase PP1-γ catalytic subunit is an enzyme encoded by the PPP1CC gene in humans. A novel phosphatidic acid (PA) binding region on PP1c-γ is identified that contains a unique loop-strand structural fold responsible for the interaction with PA. PP1c γ may function as a mediator of PA action in cells. There may be an existence of a specific high affinity PA-binding domain on the enzyme. Its overexpression promotes vascular smooth muscle cell survival by interfering with JNK1 and p⁵³ phosphorylation cascades involved in apoptosis.

Solution in phosphate buffered saline containing 0.02% sodium azide.

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