Anti-DNMT3A2 antibody produced in chicken

Chicken polyclonal anti-DNMT3A2 antibody reacts with human, rat, and mouse DNA (cytosine-5-)-methyltransferase 3 α 2 methyltransferases.

DNA (cytosine-5-)-methyltransferase 3 α (DNMT3A2) is involved in the epigenetic modification of genes involved in processes that regulate embryonic development, imprinting, and X-chromosome inactivation. For instance DNMT3A promotes the down regulation of Oct-3/4 to prevent reprogramming during early cell differentiation from the pluripotent state. Dysfunctional DNMT3A have been associated with incidence of acute myeloid leukemia (AML).

Immunogen Sequence: GI # 28559069, sequence 1-300

Recombinant DNA cytosine methyltransferase 3 α isoform a

Chicken polyclonal anti-DNMT3A2 antibody is used to tag DNA (cytosine-5-)-methyltransferase 3 α 2 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of DNA (cytosine-5-)-methyltransferase 3 α 2 in post-translational (epigenetic) gene regulation involving the processes of embryonic development, imprinting, and X-chromosome inactivation.

Solution in phosphate buffered saline containing 0.02% sodium azide.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.