Anti-ERB antibody produced in chicken

Estrogen receptor β (ERB) belongs to a family of nuclear receptors, which function as regulators of homeostasis. There are two types of ER- ERα and ERβ, and ERs form the class I of nuclear receptors. They are normally sequestered as multi-protein complex in the cytoplasm, until activated by their ligands. It contains a DNA-binding domain, a hinge domain, and AF1 domain, and a ligand-binding domain. It has a high level of expression in normal breast cells.

Immunogen Sequence: GI # 10835013, sequence 1-150

Recombinant estrogen receptor β isoform 1

Anti-ERB antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Estrogen receptor β (ERB) functions as a transcription factor, and modulates the transcription of target genes, which are components of cell cycle including cyclins and proto-oncogenes. It activates growth-inhibitory genes and thus, functions in suppressing cell proliferation. It negates the activation of anti-apoptotic genes by ERα, via 17β-estradiol. It is inactivated in breast cancer (BC), which marks an important stage in the progression of BC, in an estrogen-dependent manner. The presence of this gene is BC has prognostic value for tamoxifen-treated patients, and might also have potential as a therapeutic target. Mitochondrial ERβ2 has anti-apoptotic functions, and thus predicts poor prognosis in serous ovarian cancer.

Solution in phosphate buffered saline containing 0.02% sodium azide.