生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
制造商/商品名称
Genway 15-288-22754
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... ITGB1(3688)
应用
Anti-Integrin β1 antibody produced in chicken was used in western blot analysis of amoeba whole-cell lysates and membrane fractions for the detection of integrin-like proteins. It is also suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Integrin β-1 is a protein encoded by the ITGB1 gene in humans and regulates multiple epithelial cell functions by connecting cells with the extracellular matrix. It helps in enhancing epithelial-to-mesenchymal transition (EMT) through FAK-AKT signaling pathway. The protein expression may have potential in identifying the stage of colorectal liver metastases and may act as a marker of prognosis in these patients.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Nikolaos Vassos et al.
International journal of clinical and experimental pathology, 7(1), 288-300 (2014-01-16)
Integrins are cell surface adhesion molecules (CAM) that regulate via intercellular and cell-matrix signaling various cellular processes including wound healing, cell differentiation, division, growth, migration and metastatic dissemination. Although a correlation between carcinogenesis and changes in integrin expression, especially β1
Nancy Ernst et al.
PloS one, 8(12), e84356-e84356 (2014-01-05)
β1 integrin regulates multiple epithelial cell functions by connecting cells with the extracellular matrix (ECM). While β1 integrin-mediated signaling in murine epithelial stem cells is well-studied, its role in human adult epithelial progenitor cells (ePCs) in situ remains to be
Lixia Ju et al.
Cancer biomarkers : section A of Disease markers, 13(5), 329-336 (2014-01-21)
We have previously shown that integrinβ1 associates with gefitinib resistance. As epithelial-mesenchymal transition (EMT) also induces gefitinib resistance in vitro, we wished to determine the relation of them in gefitinib resistance. In this study, we show that integrinβ1 induced epidermal
The cytoplasmic extension of the integrin β6 subunit regulates epithelial-to-mesenchymal transition.
Carlin Lee et al.
Anticancer research, 34(2), 659-664 (2014-02-11)
Prognosis for oral cancer patients has not improved in over 60 years due to invasion and recurrence. To understand the invasive behavior of this tumor, we evaluated the role of the αvβ6 integrin. Invasive oral SCC cells express the αvβ6
Melissa Jamerson et al.
Microbiology (Reading, England), 158(Pt 3), 791-803 (2012-01-10)
Naegleria fowleri and Naegleria lovaniensis are closely related free-living amoebae found in the environment. N. fowleri causes primary amoebic meningoencephalitis (PAM), a rapidly fatal disease of the central nervous system, while N. lovaniensis is non-pathogenic. N. fowleri infection occurs when
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