GW22763
Anti-GAPDH antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Gapdh Antibody Sigma, Gapdh Antibody Sigma - Anti-GAPDH antibody produced in chicken
生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, mouse, human
制造商/商品名称
Genway 15-288-22763
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GAPDH(2597)
免疫原
Immunogen Sequence: GI # 7669492, sequence 51-290
Recombinant glyceraldehyde-3-phosphate dehydrogenase
应用
Anti-GAPDH antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化/生理作用
Glyceraldehyde 3-phosphate dehydrogenase (G3PDH) is an enzyme that catalyzes the sixth step of glycolysis and serves to break down glucose for energy and carbon molecules. It is an obligatory enzyme in glycolysis and performs a critical role in cellular regulation. GAPDH also plays a critical role in apoptosis and age-related neurodegenerative diseases, such as Alzheimer′s, Huntington′s and Parkinson′s diseases. Overexpression of this gene in resected tumor samples is an adverse prognostic factor in non-small cell lung cancers (NSCLC). It is used as a stable housekeeping marker for constant gene expression and its transcriptional levels may be highly up-regulated in some cancers.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Andres E Perez Bay et al.
Nature communications, 7, 11550-11550 (2016-05-18)
The basolateral recycling and transcytotic pathways of epithelial cells were previously defined using markers such as transferrin (TfR) and polymeric IgA (pIgR) receptors. In contrast, our knowledge of the apical recycling pathway remains fragmentary. Here we utilize quantitative live-imaging and
Tingting Li et al.
The Journal of biological chemistry, 289(6), 3775-3785 (2013-12-24)
The altered metabolism in most tumor cells consists of elevated glucose uptake and increased glycolysis even in the presence of high oxygen tension. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an obligatory enzyme in glycolysis. Here, we report that acetylation at lysine 254
Roberto Puzone et al.
Molecular cancer, 12(1), 97-97 (2013-08-31)
Glycolysis in presence of oxygen with high glucose consumption is known to be the metabolism of choice in many tumors. In lung cancer this phenomenon is routinely exploited in diagnostic PET imaging of fluorodeoxyglucose uptake, but not much is known
Aleksandra Rodacka
Postepy higieny i medycyny doswiadczalnej (Online), 67, 775-789 (2013-09-11)
For a long time glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was considered a classical glycolytic protein of little interest. It was also used as a model protein for analysis of protein structure and enzyme mechanisms. However, recent evidence demonstrates that GAPDH from mammalian
Ruidong Liu et al.
OncoTargets and therapy, 12, 7801-7808 (2019-10-03)
Osteosarcoma is the most common bone tumor with high metastasis and recurrence rate. MicroRNA-19a (miR-19a) has been reported to act as tumor oncogene in multiple cancers. The objective of the study was to explore the molecular mechanisms of miR-19a in
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