Anti-AKT2 antibody produced in chicken

Immunogen Sequence: GI # 4502023, sequence 108-124

Synthetic peptide sequence of V-akt murine thymoma viral oncogene homolog 2.

Anti-AKT2 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

RAC-β serine/threonine-protein kinase is an enzyme encoded by the AKT2 gene in humans and is mapped to chromosome region 19q13.1-q13.2. It belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains. Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas. The protein kinase is thought to be a key mediator of the insulin signal transduction process and plays a role in glucose metabolism. It also mediates the development or maintenance of proper adipose tissue and islet mass. It is an important protein in PI3K signaling pathway and is overexpressed in a variety of malignant tumors. AKT2 may be a useful molecular marker for predicting the prognosis of meningioma. It plays a novel role in neuroblastoma tumorigenesis and may be important for developing novel therapeutics for the treatment of clinically aggressive neuroblastoma.

Solution in phosphate buffered saline containing 0.02% sodium azide.

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