生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human, rat
制造商/商品名称
Genway 15-288-22822
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CALBRAIN(9478)
一般描述
The previously assigned protein identifier Q8N6H5 has been merged into Q9NZU7. Full details can be found on the UniProt database.
免疫原
Immunogen Sequence: GI # 13929432, sequence 15-227
Recombinant calcium binding protein 1 isoform 1
应用
Anti-CABP1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Calcium binding protein 1 is a protein encoded by the CABP1 gene in humans and belongs to neuron-specific member of the calmodulin (CaM) superfamily. It is a 19.4kDa protein of the EF-hand superfamily that modulates the activity of Ca2+ channels in the brain and retina. CABP1 helps in regulating the Ca2+ -dependent activity of inositol 1,4,5-triphosphate receptors (InsP3Rs) and various voltage-gated Ca2+ channels. CaBP1 interacts with cytosolic N- and C-terminal domains and blunts Ca2+-dependent inactivation. It may regulate Ca2+-dependent activity of InsP3Rs by promoting structural contacts between the suppressor and core domains.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Jennifer N Wingard et al.
The Journal of biological chemistry, 280(45), 37461-37470 (2005-09-09)
CaBP1 (calcium-binding protein 1) is a 19.4-kDa protein of the EF-hand superfamily that modulates the activity of Ca(2+) channels in the brain and retina. Here we present data from NMR, microcalorimetry, and other biophysical studies that characterize Ca(2+) binding, Mg(2+)
CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels.
Shimrit Oz et al.
The Journal of biological chemistry, 286(16), 13945-13953 (2011-03-09)
CaBP1 is a Ca(2+)-binding protein that regulates the gating of voltage-gated (Ca(V)) Ca(2+) channels. In the Ca(V)1.2 channel α(1)-subunit (α(1C)), CaBP1 interacts with cytosolic N- and C-terminal domains and blunts Ca(2+)-dependent inactivation. To clarify the role of the α(1C) N-terminal
Congmin Li et al.
The Journal of biological chemistry, 284(4), 2472-2481 (2008-11-15)
Calcium-binding protein 1 (CaBP1), a neuron-specific member of the calmodulin (CaM) superfamily, modulates Ca2+-dependent activity of inositol 1,4,5-trisphosphate receptors (InsP3Rs). Here we present NMR structures of CaBP1 in both Mg2+-bound and Ca2+-bound states and their structural interaction with InsP3Rs. CaBP1
Saebomi Park et al.
Protein science : a publication of the Protein Society, 20(8), 1356-1366 (2011-05-25)
Calcium-binding protein 1 (CaBP1), a neuron-specific member of the calmodulin (CaM) superfamily, regulates the Ca(2+) -dependent activity of inositol 1,4,5-triphosphate receptors (InsP3Rs) and various voltage-gated Ca(2+) channels. Here, we present the NMR structure of full-length CaBP1 with Ca(2+) bound at
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