Anti-GGH antibody produced in chicken

GGH (γ-glutamyl hydrolase) gene is composed of nine exons, and is 24kb in size. It encodes a peptidase which is localized to lysosomes. It is a homodimer composed of eleven α-helices, and fourteen β-strands. Its central region contains three and five α-helices sandwiching eight stranded β-sheets.

Immunogen Sequence: GI # 4503987, sequence 25-116

Recombinant gamma-glutamyl hydrolase

Anti-GGH antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

γ-glutamyl hydrolase plays an important role in the metabolism of folic acid and the pharmacology of antifolates (such as methotrexate). GGH may play a relevant role in the development and progression of invasive breast cancer and may act as an attractive targeted therapy. Polymorphism in the gene is associated with efficacy and side effects of methotrexate for treatment of acute lymphoblastic leukemia (ALL).

Solution in phosphate buffered saline containing 0.02% sodium azide.

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