H0261
DL-β-羟基丁酰基辅酶 A 锂盐
≥90%
别名:
DL -3-羟基丁酰辅酶A
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关于此项目
经验公式（希尔记法）:
C25H42N7O18P3S
化学文摘社编号:
分子量:
853.62
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
生物来源
synthetic (Organic)
方案
≥90%
表单
powder
溶解性
H2O: soluble-50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
[Li].CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23
InChI
1S/C25H42N7O18P3S.Li.H/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32;;/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41);;
InChI key
HNPHARRBSFXZAL-UHFFFAOYSA-N
应用
DL-β-羟基丁酰辅酶A锂盐已用于：
- 作为HSD17B4蛋白酶检测的底物
- 作为Hc-DHS-28及突变蛋白特异性和动力学检测底物
- 作为S-腺苷-L-高半胱氨酸水解酶(AHCY)体外乙酰化反应的缓冲液组分
生化/生理作用
3-羟基丁酰基辅酶 A (HBCoA) 通过聚羟基丁酸 (PHB) 合成酶转化为细菌聚羟基脂肪酸酯 (PHB)。3-羟基丁酰基辅酶 A 是用于测定 β-羟酰 CoA 脱氢酶。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.
Cornille E, Abou-Hamdan M, et al.
BMC Neuroscience, 23, 51-51 (2010)
Der-Shyan Sheu et al.
Analytical biochemistry, 393(1), 62-66 (2009-06-17)
This study presents a method to detect active polyhydroxyalkanoate (PHA) synthase on a polyacrylamide gel that combines the polyhydroxybutyrate (PHB) polymerization reaction with Sudan Black B staining. After separation of the protein samples on a modified sodium dodecyl sulfate-polyacrylamide gel
Yi Yang et al.
International journal for parasitology, 50(12), 945-957 (2020-08-29)
Haemonchus contortus could enter the diapause stage to avoid hostile conditions, however the inducing mechanism still remains poorly understood. A similar dauer strategy exists in Caenorhabditis elegans, and dauer phenomones, which are produced through a four step cycle of peroxisomal
An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation
Xie J, et al.
CCS Chemistry, 4(1), 304-317 (2022)
Ping Li et al.
Biochemistry, 48(39), 9202-9211 (2009-08-29)
Polyhydroxybutyrate (PHB) synthases catalyze the conversion of 3-hydroxybutyryl coenzyme A (HBCoA) to PHB with a molecular mass of 1.5 MDa. The class III synthase from Allochromatium vinosum is a tetramer of PhaEPhaC (each 40 kDa). The polymerization involves covalent catalysis
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