H0541
Anti-HOXB7 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-HHO.C1, Anti-HOX2, Anti-HOX2C, Anti-Hox-2.3
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~24 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXB7, indirect immunofluorescence: 1-2 μg/mL using using paraformaldehyde fixed HEK-293T cells over expressing human HOXB7, western blot: 1-2 μg/mL using extracts of HEK-293T cells over expressing human HOXB7
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HOXB7(3217)
mouse ... Hoxb7(15415)
General description
Homeobox B7 (HOXB7) gene is mapped to human chromosome 17q21.32. In vertebrates, 39 HOX genes are organized into four clusters (HOXA-HOXD), located on different chromosomes (7p15, 17q21.2, 12q13, and 2q31). HOX proteins have a highly conserved 60-amino-acid region (the homeobox).
Application
Anti-HOXB7 (C-terminal) antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Anti-HOXB7 (C-terminal) recognizes human HOXB7 (also known as HOX2; HOX2C; HHO.
The homeobox with DNA-binding activity, contributes to their activity as transcription factors. Hox genes are evolutionarily conserved transcription factors, which act to control important development pathways involved in the morphogenesis of the embryo. HOXB7 is expressed in various human hematopoietic cell lines and tissues as well as in proliferating melanocytes. In addition to roles in normal development, altered homeobox gene function or expression is implicated in carcinomas associated with breast, prostate, kidney, colon, skin and brain.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Dong Gao et al.
American journal of physiology. Cell physiology, 315(5), C675-C686 (2018-08-02)
Metastatic cutaneous squamous cell carcinoma (CSCC) is a major cause of death associated with nonmelanoma skin cancer. The involvement of homeobox B7 ( HOXB7) in cancers has been reported. Thus, the current study intends to explore the effect of HOXB7
Elisabetta Manuela Foppiani et al.
Stem cell research & therapy, 10(1), 101-101 (2019-03-21)
The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing
M T Lewis
Breast cancer research : BCR, 2(3), 158-169 (2001-03-16)
Both normal development and neoplastic progression involve cellular transitions from one physiological state to another. Whereas much is being discovered about signal transduction networks involved in regulating these transitions, little progress has been made in identifying the higher order genetic
Yang Yang et al.
Molecular medicine reports, 16(3), 2773-2778 (2017-07-06)
Osteosarcoma is the most common primary malignant bone cancer in children and adolescents. Unfortunately, treatment failures are common due to metastasis and chemore-sistance, however, the underlying molecular mechanism remains unclear. Accumulating evidence indicated that the homeobox B7 (HOXB7) gene was
Nobumoto Tomioka et al.
Cancer genetics and cytogenetics, 201(1), 6-14 (2010-07-17)
Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification
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