H1142
15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
~150 μg/mL in ethanol, ≥97.0% (HPLC)
别名:
(15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid, (S)-15-HETE, 15(S)-HETE
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H32O3
化学文摘社编号:
分子量:
320.47
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
2470466
MDL number:
SMILES string
CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O
InChI
1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
InChI key
JSFATNQSLKRBCI-VAEKSGALSA-N
assay
≥97.0% (HPLC)
concentration
~150 μg/mL in ethanol
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
57.2 °F - closed cup
flash_point_c
14 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Li-Xing Tian et al.
Cellular immunology, 349, 104047-104047 (2020-02-06)
The polarization of macrophages is critical to inflammation and tissue repair, with unbalanced macrophage polarization associated with critical dysfunctions of the immune system. Cytochrome P450 1A1 (CYP1A1) is a hydroxylase mainly controlled by the inflammation-limiting aryl hydrocarbon receptor (AhR), which
Cui Ma et al.
Hypertension (Dallas, Tex. : 1979), 58(4), 679-688 (2011-08-24)
We have found that 15-hydroxyeicosatetraenoic acid (15-HETE) induced by hypoxia was an important mediator in the regulation of hypoxic pulmonary hypertension, including the pulmonary vasoconstriction and remodeling. However, the underlying mechanisms of the remodeling induced by 15-HETE are poorly understood.
Eicosanoids in inflammatory skin diseases.
K Fogh et al.
Prostaglandins & other lipid mediators, 63(1-2), 43-54 (2000-12-05)
M Profita et al.
American journal of physiology. Cell physiology, 279(4), C1249-C1258 (2000-09-26)
We evaluated the levels of 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE] and the expression of 15-lipoxygenase (15-LO) mRNA in induced sputum obtained from 10 control and 15 chronic bronchitis subjects. 15(S)-HETE was evaluated by reverse phase high-performance liquid chromatography separation followed by specific
Gabrielle Fredman et al.
PloS one, 6(9), e24422-e24422 (2011-09-22)
Resolution of inflammation is an active temporally orchestrated process demonstrated by the biosynthesis of novel proresolving mediators. Dysregulation of resolution pathways may underlie prevalent human inflammatory diseases such as cardiovascular diseases and periodontitis. Localized Aggressive Periodontitis (LAP) is an early
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持