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经验公式(希尔记法):
C13H14N2O · HCl · 2H2O
化学文摘社编号:
分子量:
286.75
UNSPSC Code:
12352200
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6493114
InChI
1S/C13H14N2O.ClH.2H2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;;;/h3-4,7,15H,5-6H2,1-2H3;1H;2*1H2
SMILES string
Cl[H].[H]O[H].[H]O[H].COc1ccc2c3CCN=C(C)c3[nH]c2c1
InChI key
LCEKUHFBUFUSSY-UHFFFAOYSA-N
assay
≥95%
drug control
stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada
application(s)
forensics and toxicology
storage temp.
−20°C
Biochem/physiol Actions
中枢神经系统兴奋剂;可通过 NMDA 受体起作用
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 2
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
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Neurochemical research, 45(7), 1518-1525 (2020-03-17)
Essential tremor is one of the most common neurological disorders, however, it is not sufficiently controlled with currently available pharmacotherapy. Our recent study has shown that pramipexole, a drug efficient in inhibiting parkinsonian tremor, reduced the harmaline-induced tremor in rats
Fatemeh Mohammadi et al.
Neuroscience letters, 704, 153-158 (2019-04-12)
There are conflicting reports concerning the association of motor disabilities with increased risk of mental disorders. This investigation will provide a good understanding about defining the possible association between tremor and risk of anxiety and cognitive alterations. Beside, a secondary
Sarah Eller et al.
Forensic science international, 312, 110298-110298 (2020-05-11)
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Hassan Abbassian et al.
British journal of pharmacology, 173(22), 3196-3207 (2016-10-21)
Essential tremor (ET) is a neurological disorder with unknown aetiology. Its symptoms include cerebellar motor disturbances, cognitive and personality changes, hearing and olfactory deficits. Hyperactivity of excitotoxic cerebellar climbing fibres may underlie essential tremor and has been induced in rodents
Amanda M Brown et al.
eLife, 9 (2020-03-18)
Tremor is currently ranked as the most common movement disorder. The brain regions and neural signals that initiate the debilitating shakiness of different body parts remain unclear. Here, we found that genetically silencing cerebellar Purkinje cell output blocked tremor in
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