H141
S(−)-8-Hydroxy-DPAT hydrobromide
solid
别名:
S(−)-8-OH-DPAT HBr
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关于此项目
经验公式（希尔记法）:
C16H25NO · HBr
化学文摘社编号:
分子量:
328.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
solid
optical activity
[α]25/D −67.8° in methanol(lit.)
color
white
SMILES string
Br.CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
InChI
1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m0./s1
InChI key
BATPBOZTBNNDLN-UQKRIMTDSA-N
Biochem/physiol Actions
Partial 5-HT1A serotonin receptor agonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
L Björk et al.
Journal of medicinal chemistry, 32(4), 779-783 (1989-04-01)
The enantiomers of the N,N-dimethylamino (1), N,N-diethylamino (2), and N,N-dibutylamino (4) derivatives of 8-hydroxy-2-(dipropylamino)tetralin (8-OH DPAT; 3) have been synthesized. The compounds have been tested for activity at central 5-hydroxytryptamine and dopamine receptors by use of biochemical and behavioral tests
L J Cornfield et al.
Molecular pharmacology, 39(6), 780-787 (1991-06-01)
Although many different types of compounds have been tested for 5-hydroxytryptamine1A (5-HT1A) binding affinity, much remains to be learned about the structural requirements associated with 5-HT1A agonism, partial agonism, and antagonism. The present study uses the forskolin-stimulated adenylate cyclase (FSC)
Maarten van den Buuse
ACS chemical neuroscience, 4(1), 149-160 (2013-01-22)
Prepulse inhibition (PPI) is a model of sensorimotor gating, a sensory filtering mechanism which is disrupted in schizophrenia. Here, investigation of the role of the serotonin-1A (5-HT(1A)) receptor in the regulation of PPI in two mouse strains, C57Bl/6 and Balb/c
Nina Nevalainen et al.
PloS one, 8(2), e55706-e55706 (2013-02-08)
L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-l-alanine (l-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The
Stéphanie Fournier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(2), 563-573 (2013-01-11)
Recurrent apneas are important causes of hospitalization and morbidity in newborns. Gestational stress (GS) compromises fetal brain development. Maternal stress and anxiety during gestation are linked to respiratory disorders in newborns; however, the mechanisms remain unknown. Here, we tested the
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