H149
氢氯噻嗪
别名:
6-氯-3,4-二氢-2H-1,2,4-苯并噻二嗪-7-磺酰胺1,1-二氧化物, 6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物
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关于此项目
经验公式（希尔记法）:
C7H8ClN3O4S2
化学文摘社编号:
分子量:
297.74
EC Number:
200-403-3
UNSPSC Code:
41116107
MDL number:
InChI key
JZUFKLXOESDKRF-UHFFFAOYSA-N
InChI
1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
SMILES string
NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl
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General description
Hydrochlorothiazide is a type of thiazide diuretics used as a hypertensive agent.
Application
Hydrochlorothiazide may be used as a reference standard in the determination of hydrochlorothiazide in pharmaceutical formulations using first-derivative ultraviolet spectrophotometry and high-performance liquid chromatography (HPLC).
Biochem/physiol Actions
碳酸酐酶抑制剂
signalword
Warning
hcodes
Hazard Classifications
Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Simultaneous determination of valsartan and hydrochlorothiazide in tablets by first-derivative ultraviolet spectrophotometry and LC.
Satana E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 25(5-6), 1009-1013 (2001)
Ahmed H Ahmed et al.
Journal of medicinal chemistry, 53(5), 2197-2203 (2010-02-19)
Glutamate receptors are the most prevalent excitatory neurotransmitter receptors in the vertebrate central nervous system and are important potential drug targets for cognitive enhancement and the treatment of schizophrenia. Allosteric modulators of AMPA receptors promote dimerization by binding to a
Barry L Carter et al.
Hypertension (Dallas, Tex. : 1979), 43(1), 4-9 (2003-11-26)
Thiazide diuretics are one of the preferred pharmacologic treatments for hypertension. Hydrochlorothiazide and chlorthalidone have been the 2 most commonly used diuretics in major clinical trials. Treatment guidelines and compendia often consider these 2 drugs interchangeable agents within the class
Loretta Aureli et al.
Journal of medicinal chemistry, 48(7), 2469-2479 (2005-04-02)
A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities. These CXCL8 inhibitors are derivatives of phenylpropionic nonsteroidal antiinflammatory drugs (NSAIDs), high-affinity ligands for site II of human serum albumin
Pil H Lee et al.
Bioorganic & medicinal chemistry letters, 20(1), 69-73 (2009-12-08)
A multiple linear regression QSAR model was developed based on a set of 61 compounds with internally consistent permeability data measured across Franz cell. The data was normalized using a mean permeability value of a reference compound, 3-isobutyl-1-methylxanthine (IBMX). The
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