H156
(+)-3-Hydroxymorphinan hydrobromide
neurotrophic to dopaminergic neurons
别名:
(+)-9α,13α,14α-Morphinan-3-ol
描述
neurotrophic to dopaminergic neurons
方案
≥98% (HPLC)
表单
powder
药品控制
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
SMILES字符串
Br.Oc1ccc2C[C@@H]3NCC[C@]4(CCCC[C@H]34)c2c1
InChI
1S/C16H21NO.BrH/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12;/h4-5,10,13,15,17-18H,1-3,6-9H2;1H/t13-,15+,16+;/m1./s1
InChI key
LJAQABDSIONCIU-KHUAAREISA-N
O Mortimer et al.
British journal of clinical pharmacology, 27(2), 223-227 (1989-02-01)
1. The interindividual differences in serum concentrations of dextromethorphan (DM) and its metabolites were studied in 29 healthy subjects given 120 mg orally. They were also phenotyped according to the urinary ratio of debrisoquine and 4-hydroxy-debrisoquine. 2. Four (14%) subjects
N Nagai et al.
Biopharmaceutics & drug disposition, 17(5), 421-433 (1996-07-01)
The plasma concentration and cumulative urinary excretion over 34 h of dextromethorphan, free and conjugated dextrorphan, and 3-hydroxymorphinan were determined in seven healthy Japanese subjects after oral administration of 30 mg dextromethorphan hydrobromide. Conjugated metabolites were extensively present, whereas no
High-performance liquid chromatographic determination of dextrorphan and 3-hydroxymorphinan in human plasma based on a selective pre-column sample clean-up.
H Mascher
Journal of chromatography, 420(1), 217-222 (1987-09-04)
Z R Chen et al.
Therapeutic drug monitoring, 12(1), 97-104 (1990-01-01)
A simple, sensitive, and reproducible high-performance liquid chromatrography assay is described for the simultaneous determination of dextromethophan, dextrorphan, 3-hydroxymorphinan, and 3-methoxymorphinan in plasma and urine. A conventional solvent-solvent extraction procedure was used for the isolation of the analytes from plasma
Jong Yup Kim et al.
Chemical & pharmaceutical bulletin, 56(7), 985-987 (2008-07-02)
Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available
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