H2164
Anti-HP1α antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Antigen p25, Anti-Chromobox Protein Homolog 5, Anti-Heterochromatin Protein 1 Homolog α
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关于此项目
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB CL
Citations:
7
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~22 kDa
species reactivity
human, mouse
technique(s)
immunoprecipitation (IP): 5-10 μg using RIPA lysate of human HeLa cells, indirect immunofluorescence: 5-10 μg/mL using mouse NIH3T3 cells, western blot (chemiluminescent): 1-2 μg/mL using whole extract of human HeLa cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CBX5(23468)
mouse ... Cbx5(12419)
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Immunogen
synthetic peptide corresponding to amino acid residues 177-191 of human HP1a with N-terminal added cysteine, conjugated to KLH. The corresponding sequence in mouse differs by one amino acid.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin.
Christèle Maison et al.
Nature communications, 7, 12224-12224 (2016-07-19)
The trimethylation of histone H3 on lysine 9 (H3K9me3) - a mark recognized by HP1 that depends on the Suv39h lysine methyltransferases (KMTs) - has provided a basis for the reader/writer model to explain HP1 accumulation at pericentric heterochromatin in
Shinichi Machida et al.
Molecular cell, 69(3), 385-397 (2018-01-18)
Heterochromatin plays important roles in transcriptional silencing and genome maintenance by the formation of condensed chromatin structures, which determine the epigenetic status of eukaryotic cells. The trimethylation of histone H3 lysine 9 (H3K9me3), a target of heterochromatin protein 1 (HP1), is
Alba Millanes-Romero et al.
Molecular cell, 52(5), 746-757 (2013-11-19)
Although heterochromatin is enriched with repressive traits, it is also actively transcribed, giving rise to large amounts of noncoding RNAs. Although these RNAs are responsible for the formation and maintenance of heterochromatin, little is known about how their transcription is
Julio Aguado et al.
Nature communications, 10(1), 4990-4990 (2019-11-20)
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction
Joseph Dopie et al.
The Journal of cell biology, 219(9) (2020-07-02)
We present a simple ratio method to infer protein composition within cellular structures using proximity labeling approaches but compensating for the diffusion of free radicals. We used tyramide signal amplification (TSA) and label-free mass spectrometry (MS) to compare proteins in
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